{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:46:34Z","timestamp":1792075594711,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:00:00Z","timestamp":1592006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012023","name":"Stichting Sanquin Bloedvoorziening","doi-asserted-by":"publisher","award":["PPO 18\u201014\/L2337"],"award-info":[{"award-number":["PPO 18\u201014\/L2337"]}],"id":[{"id":"10.13039\/501100012023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Whole blood donors are at risk of becoming iron deficient. To monitor iron stores, Sanquin implemented a new deferral policy based on ferritin levels, in addition to the traditional hemoglobin measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Ferritin levels are determined in every fifth donation, as well as in all first\u2010time donors. Donors with ferritin levels &lt;15\u2009ng\/mL (WHO threshold) are deferred for 12\u2009months; those \u226515 and \u226430\u2009ng\/mL for 6\u2009months. The first results were analyzed and are presented here.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The results show that 25% of women (N = 20151, 95% CI 24%\u201025%) and 1.6% of men (N = 10391, 95% CI 1.4%\u20101.8%) have ferritin levels \u226430\u2009ng\/mL at their first blood center visit. For repeat (non\u2010first\u2010time) donors, these proportions are higher: 53% of women (N = 28329, 95% CI 52%\u201054%) and 42% of men (N = 31089, 95% CI 41%\u201043%). After a 6\u2010month deferral, in 88% of returning women (N = 3059, 95% CI 87%\u201089%) and 99% of returning men (N = 3736, 95% CI 98%\u201099%) ferritin levels were \u226515\u2009ng\/mL. After a 12\u2010month deferral, in 74% of returning women (N = 486, 95% CI 70%\u201078%) and 95% of returning men (N = 479, 95% CI 94%\u201097%) ferritin levels increased to \u226515\u2009ng\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Deferral of donors whose pre\u2010donation ferritin levels were \u226430\u2009ng\/mL might prevent donors from returning with ferritin levels &lt;15\u2009ng\/mL. This policy is promising to mitigate effects of repeated donations on iron stores.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15906","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T07:29:04Z","timestamp":1592033344000},"page":"1785-1792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["First results of a ferritin\u2010based blood donor deferral policy in the Netherlands"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5653-8078","authenticated-orcid":false,"given":"Marieke","family":"Vinkenoog","sequence":"first","affiliation":[{"name":"Donor Medicine Research, Sanquin Research  Amsterdam The Netherlands"},{"name":"Leiden Institute of Advanced Computer Science Leiden University  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"van den Hurk","sequence":"additional","affiliation":[{"name":"Donor Medicine Research, Sanquin Research  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"van Kraaij","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Sanquin Blood Bank  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Leiden Institute of Advanced Computer Science Leiden University  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1682-7817","authenticated-orcid":false,"given":"Mart P.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Donor Medicine Research, Sanquin Research  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"FinchCA CookJD LabbeRF CulalaM. Effect of blood donation on iron stores as evaluated by serum ferritin. Vol. 50; 1977 [cited 2019 May 10]. Available from:www.bloodjournal.org.","DOI":"10.1182\/blood.V50.3.441.bloodjournal503441"},{"key":"e_1_2_8_3_1","volume-title":"Smith JL","author":"Gropper SS","year":"2012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15136"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.1529"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.119"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-04-709451"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12527"},{"key":"e_1_2_8_9_1","volume-title":"Serum ferritin concentrations for the assessment of iron status and iron deficiency in populations","author":"World Health Organization","year":"2011"},{"key":"e_1_2_8_10_1","first-page":"164","article-title":"Review on iron and its importance for human health","volume":"19","author":"Abbaspour N","year":"2014","journal-title":"J Res Med Sci"},{"key":"e_1_2_8_11_1","unstructured":"Sanquin Blood Supply Foundation. Sanquin Annual Report 2018 Amsterdam. Available from:https:\/\/www.sanquin.nl\/binaries\/content\/assets\/sanquinen\/about-sanquin\/annual-reports\/sanquin_annual_report_2018.pdf."},{"key":"e_1_2_8_12_1","unstructured":"R Core Team. R: a language and environment for statistical computing. 2019. [accessed 2019 April 30] Available from:https:\/\/www.r-project.org\/."},{"key":"e_1_2_8_13_1","unstructured":"WickhamH.Ggplot2: elegant graphics for data analysis. New York: Springer\u2010Verlag; 2016. [accessed 2019 April 30] Available from:https:\/\/ggplot2.tidyverse.org."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3324-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01698138"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1991.tb00136.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31928-1"},{"key":"e_1_2_8_18_1","unstructured":"MittalR MarwahaN BasuS MohanH Ravi KumarA. Evaluation of iron stores in blood donors by serum ferritin. 2007 [cited 2019 Nov 22]. 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