{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T21:56:02Z","timestamp":1784152562868,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>A novel coronavirus has caused an international outbreak. Currently, there are no specific therapeutic agents for coronavirus infections. Convalescent plasma (CP) therapy is a potentially effective treatment option.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients who had recovered from COVID\u201019 and had been discharged from the hospital for more than 2\u2009weeks were recruited. COVID\u201019 convalescent plasma (CCP)\u2010specific donor screening and selection were performed based on the following criteria: 1) aged 18\u201055\u2009years; 2) eligible for blood donation; 3) diagnosed with COVID\u201019; 4) had two consecutive negative COVID\u201019 nasopharyngeal swab tests based on PCR (at least 24\u2009hr apart) prior to hospital discharge; 5) had been discharged from the hospital for more than 2\u2009weeks; and 6) had no COVID\u201019 symptoms prior to convalescent plasma donation. In addition, preference was given to CCP donors who had a fever lasting more than 3\u2009days or a body temperature exceeding 38.5\u00b0C (101.3\u00b0F), and who donated 4\u2009weeks after the onset of symptoms. CCP collection was performed using routine plasma collection procedures via plasmapheresis. In addition to routine donor testing, the CCP donors\u02bc plasma was also tested for SARS\u2010CoV\u20102 nucleic acid and S\u2010RBD\u2010specific IgG antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of the 81 potential CCP donors, 64 (79%) plasma products were collected. There were 18 female donors and 46 male donors. There were 34 first\u2010time blood donors and 30 repeat donors. The average time between CCP collection and initial symptom onset was 49.1\u2009days, and the average time between CCP collection and hospital discharge was 38.7\u2009days. The average volume of CCP collected was 327.7 mL.<\/jats:p><jats:p>All Alanine transaminase (ALT) testing results met blood donation requirements. HIV Ag\/Ab, anti\u2010HCV, anti\u2010syphilis, and HBsAg were all negative; NAT for HIV, HBV, and HCV were also negative. In addition, all of the CCP donors\u02bc plasma units were negative for SARS\u2010CoV\u20102 RNA. Of the total 64 CCP donors tested, only one had an S\u2010RBD\u2010specific IgG titer of 1:160, all others had a titer of \u22651:320.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Based on a feasibility study of a pilot CCP program in Wuhan, China, we demonstrated the success and feasibility of CCP collection. In addition, all of the CCP units collected had a titer of \u22651:160 for S\u2010RBD\u2010specific IgG antibody, which met the CCP quality control requirements based on the Chinese national guidelines for CCP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15921","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T16:11:27Z","timestamp":1591200687000},"page":"1773-1777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Feasibility of a pilot program for <scp>COVID<\/scp>\u201019 convalescent plasma collection in Wuhan, China"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-6251","authenticated-orcid":false,"given":"Ling","family":"Li","sequence":"first","affiliation":[{"name":"Clinical Transfusion Research Center Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College  Chengdu Sichuan China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Yang","sequence":"additional","affiliation":[{"name":"Wuhan Blood Center  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Research Center Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College  Chengdu Sichuan China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilu","family":"Lv","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Research Center Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College  Chengdu Sichuan China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Ren","sequence":"additional","affiliation":[{"name":"Wuhan Blood Center  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Wuhan Blood Center  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuhan Blood Center  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Xu","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Research Center Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College  Chengdu Sichuan China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu Sichuan 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Fang","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Research Center Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College  Chengdu Sichuan China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu Sichuan China"},{"name":"Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gong","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Research Center Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College  Chengdu Sichuan China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu Sichuan China"},{"name":"Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan Blood Center  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8410-4349","authenticated-orcid":false,"given":"Yanyun","family":"Wu","sequence":"additional","affiliation":[{"name":"University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8173-9656","authenticated-orcid":false,"given":"Zhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Research Center Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College  Chengdu Sichuan China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu Sichuan 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Available from:https:\/\/www.fda.gov\/vaccines\u2010blood\u2010biologics\/investigational\u2010new\u2010drug\u2010ind\u2010or\u2010device\u2010exemption\u2010ide\u2010process\u2010cber\/investigational\u2010covid\u201019\u2010convalescent\u2010plasma\u2010emergency\u2010inds."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15918"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.15921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.15921","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T20:35:41Z","timestamp":1693946141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.15921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/trf.15921"],"URL":"https:\/\/doi.org\/10.1111\/trf.15921","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"assertion":[{"value":"2020-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}