{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:16:07Z","timestamp":1761156967100,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Background<\/jats:title><jats:sec><jats:label\/><jats:p>Risk assessments of transfusion\u2010transmitted emerging infectious diseases (EIDs) are complicated by the fact that blood donors\u02bc demographics and behaviors can be different from the general population. Therefore, when assessing potential blood donor exposure to EIDs, the use of general population characteristics, such as U.S. travel statistics, may invoke uncertainties that result in inaccurate estimates of blood donor exposure. This may, in turn, lead to the creation of donor deferral policies that do not match actual risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>This article reports on the development of a system to rapidly assess EID risks for a nationally representative portion of the U.S. blood donor population. To assess the effectiveness of this system, a test survey was developed and deployed to a statistically representative sample frame of blood donors from five blood collecting organizations. Donors were directed to an online survey to ascertain their recent travel and potential exposure to Middle East respiratory syndrome coronavirus (MERS\u2010CoV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 7128 responses were received from 54\u2009256 invitations. The age\u2010adjusted estimated total number of blood donors potentially exposed to MERS\u2010CoV was approximately 15\u2009640 blood donors compared to a lower U.S. general population\u2010based estimate of 9610 blood donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The structured donor demographic sample\u2013based data provided an assessment of blood donors\u02bc potential exposure to an emerging pathogen that was 63% larger than the U.S. population\u2013based estimate. This illustrates the need for tailored blood donor\u2013based EID risk assessments that provide more specific demographic risk intelligence and can inform appropriate regulatory decision making.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15941","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T08:08:24Z","timestamp":1596442104000},"page":"1987-1997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use of a rapid electronic survey methodology to estimate blood donors' potential exposure to emerging infectious diseases: Application of a statistically representative sampling methodology to assess risk in US blood centers"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6311-6268","authenticated-orcid":false,"given":"Barbee I.","family":"Whitaker","sequence":"first","affiliation":[{"name":"U.S. Food and Drug Administration\/Center for Biologics 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