{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:14:04Z","timestamp":1780089244717,"version":"3.54.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["465539\/2014\u20109"],"award-info":[{"award-number":["465539\/2014\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["01.16.0048.00 \u2010 245\/2016"],"award-info":[{"award-number":["01.16.0048.00 \u2010 245\/2016"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/08135\u20102"],"award-info":[{"award-number":["2013\/08135\u20102"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/50947\u20107"],"award-info":[{"award-number":["2014\/50947\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/15049\u20103"],"award-info":[{"award-number":["2016\/15049\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 26\u2010year\u2010old woman with sickle cell disease (SCD) on chronic transfusion therapy complained of severe arthralgia, myalgia, abdominal pain, headache, and fever 24\u2009hours after transfusion of a red blood cells (RBCs). Dengue virus (DENV) infection was suspected and the patient was hospitalized for clinical support and RBC transfusion, to lower the hemoglobin\u2009S to less than 30%. The patient\u02bcs clinical condition improved approximately 8\u2009days after the onset of symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DENV type 2 (DENV\u20102) TaqMan real\u2010time polymerase chain reaction was negative in the patient's pretransfusion sample while the posttransfusion sample was positive (Ct, 27.8), suggesting a high viral load and an acute infection. To investigate DENV transfusion transmission (TT\u2010DENV) the stored donor serum was tested and was also positive (Ct, 25.8). Molecular typing confirmed the presence of DENV\u20102. The phylogenetic analysis of the DENV\u20102 strains obtained from both donor and patient samples were classified as the Southeast Asia\u2010American genotype (Genotype III) and demonstrated 100% genomic identity, indicating TT\u2010DENV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first description of TT\u2010DENV in a SCD patient. A presumed high viral load in the transfused RBC unit probably determined the early clinical manifestation. In endemic regions dengue fever should be considered as differential diagnosis in SCD patients with fever and acute pain crisis, mainly during DENV outbreaks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15968","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T13:37:20Z","timestamp":1596202640000},"page":"2139-2143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Vaso\u2010occlusive crisis in a sickle cell patient after transfusion\u2010transmitted dengue infection"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-4128","authenticated-orcid":false,"given":"Fl\u00e1via L. S.","family":"Santos","sequence":"first","affiliation":[{"name":"Regional Blood Center of Ribeir\u00e3o Preto, Faculty of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetoslav N.","family":"Slavov","sequence":"additional","affiliation":[{"name":"Regional Blood Center of Ribeir\u00e3o Preto, Faculty of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael S.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Regional Blood Center of Ribeir\u00e3o Preto, Faculty of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine V.","family":"Santos","sequence":"additional","affiliation":[{"name":"Regional Blood Center of Ribeir\u00e3o Preto, Faculty of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Silva\u2010Pinto","sequence":"additional","affiliation":[{"name":"Regional Blood Center of Ribeir\u00e3o Preto, Faculty of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L. 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