{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:49:06Z","timestamp":1790419746895,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Background<\/jats:title><jats:sec><jats:label\/><jats:p>Hemolytic disease of the fetus and newborn (HDFN) is a severe form of anemia caused by maternal antibodies against fetal red blood cells (RBC) that can cause intrauterine and perinatal morbidity and mortality. The prevalence and specificities of alloantibodies among Israeli pregnant women and clinical outcomes for their fetuses and newborns are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>A retrospective study of women who gave birth between January 1, 2011, and December 31, 2011, was performed. Data were obtained for obstetric admissions from 16 of 27 hospitals, which included results of maternal ABO, D, antibody screens, antibody identification, and requirements for intrauterine or newborn exchange transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data on 90\u2009948 women representing 70% of all births during 2011 were analyzed. Antibody screen was positive in 5245 (5.8%) women. Alloantibodies, excluding anti\u2010D titer (&lt;16) were identified in 900 (1.0%) women. Of 191 D\u2013 women, 75 (39.3%) had anti\u2010D titer of 16 or greater. Other common clinically significant antibodies were anti\u2010E (204, 23%), anti\u2010K (145, 16%), and anti\u2010c (97, 10.8%) alone or in antibody combinations. Multiple alloantibodies were observed in 132 of 900 (15%) of women. Severe HDFN developed in 6.8% (9\/132) of these pregnancies. Seventeen fetuses and newborns (0.02% of births) including one set of twins required RBC transfusions. Two fetuses whose mothers had multiple alloantibodies received intrauterine transfusions; one of them was hydropic and died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of RBC alloantibodies was 1.0% among Israeli pregnant women. Transfusion was required in 0.02% of the fetuses and newborns. Severe HDFN developed in 6.8% of pregnancies with multiple maternal alloantibodies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15987","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T14:28:57Z","timestamp":1596896937000},"page":"2684-2690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Red blood cell alloimmunization prevalence and hemolytic disease of the fetus and newborn in Israel: A retrospective study"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3411-886X","authenticated-orcid":false,"given":"Naomi","family":"Rahimi\u2010Levene","sequence":"first","affiliation":[{"name":"Blood Bank, Shamir Medical Center  Zerifin Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Chezar","sequence":"additional","affiliation":[{"name":"Blood Bank, Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vered","family":"Yahalom","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"},{"name":"Blood Services and Apheresis Institute, Rabin Medical Center  Petach Tikva Israel"},{"name":"National Blood Group Reference Laboratory, Magen David Adom, National Blood Services  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Israeli HDFN Study Group Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002528"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12265"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2016.05.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803193381204"},{"key":"e_1_2_6_6_1","volume-title":"The 2003\u20102004 Scientific Section Coordinating Committee. 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