{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:21Z","timestamp":1787016081722,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sickle cell disease (SCD) is associated with hematologic complications including delayed hemolytic transfusion reactions (DHTRs) and pregnancy\u2010related morbidity and mortality. Hyperhemolysis syndrome (HS) is the most severe form of DHTR in patients with SCD, in which both transfused and native red blood cells are destroyed. Further transfusions are avoided after a history of HS. Immunosuppressive agents can be used as prophylaxis against life\u2010threatening hemolysis when transfusion is necessary. There is a paucity of evidence for the use of HS prophylaxis before transfusions, the continuation of hydroxyurea (HU) in lieu of chronic transfusion, and the use of erythropoiesis\u2010stimulating agents (ESA) in pregnant SCD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>We present a case of a pregnant patient with SCD and a previous history of HS. HS prophylaxis was given before transfusion with corticosteroids, intravenous immunoglobulin, and rituximab. In addition, HU was continued during pregnancy to control SCD, along with the use of concomitant ESA to maintain adequate hemoglobin levels and avoid transfusion. We describe a multidisciplinary approach to pregnancy and delivery management including tailored anesthetic and obstetric planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first published case of HS prophylaxis in a pregnant SCD patient, with good maternal and fetal outcomes after transfusion. HU and ESAs were able to control SCD and mitigate anemia in lieu of prophylactic transfusions during pregnancy. Further prospective studies are necessary to elucidate the ideal management of pregnant SCD patients with a history of HS or other contraindications to chronic transfusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.16003","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T15:21:57Z","timestamp":1599060117000},"page":"2448-2455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Peripartum hyperhemolysis prophylaxis and management in sickle cell disease: A case report and narrative review"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-8597","authenticated-orcid":false,"given":"Lakshman","family":"Vasanthamohan","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematology Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonisha","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui Tammy","family":"Symons","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Clinical Pharmacology Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Eastabrook","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1518-1831","authenticated-orcid":false,"given":"Ziad","family":"Solh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology Western University  London Ontario Canada"},{"name":"Department of Pathology &amp; Laboratory Medicine, Division of Transfusion Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.09.2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15227"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2017.05.016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13144"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001143"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-785964"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24908"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13339"},{"key":"e_1_2_6_10_1","article-title":"Eleven\u2010year retrospective study of hyperhemolysis syndrome in sickle cell disease","author":"Aneke J","year":"2019","journal-title":"Can Soc Transfus Med"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2015.06.001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24460"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0251-RS"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006073222301"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2019.02.003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1994.tb00311.x"},{"key":"e_1_2_6_17_1","unstructured":"Royal College of Obstetricians and Gynaecologists.Management of Sickle Cell Disease in Pregnancy. 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