{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:12:37Z","timestamp":1783091557638,"version":"3.54.6"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019 convalescent plasma (CCP) represents an appealing approach to the treatment of patients with infections due to SARS\u2010CoV\u20102. We endeavored to quickly establish a sustainable CCP transfusion program for a regional network of health care facilities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design and methods<\/jats:title><jats:p>A regional collaborative group was activated to address the issues necessary to implementing a CCP transfusion program and making the program sustainable. A wide range of health care providers including physicians (critical care, infectious disease, transfusion medicine), nurses, pharmacists, laboratorians, and information technology (IT) specialists were required to make the program a success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CCP implementation team initially consisted of four members but quickly grew to a group of nearly 20 participants based on different issues related to program implementation. Overall, six major implementation \u201cthemes\u201d were addressed: (a) registration of individual hospitals and principal investigators with a national investigational new drug research protocol; (b) collaboration with a regional blood donor center; (c) targeted recruitment of convalesced donors; (d) IT issues related to all aspects of CCP ordering, distribution, and transfusion; (e) prioritization of patients to receive CCP; and (f) evaluation of CCP products including antibody characteristics and patient response to therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within 4\u2009weeks of initiation, CCP was successfully transfused at multiple hospitals in our regional health care delivery system. A program infrastructure was established that will make this program sustainable into the future. This approach has broader implications for the success of multi\u2010institutional programs requiring rapid implementation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16026","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T08:25:26Z","timestamp":1596529526000},"page":"2203-2209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Rapid establishment of a <scp>COVID<\/scp>\u201019 convalescent plasma program in a regional health care delivery network"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1031-8816","authenticated-orcid":false,"given":"Douglas","family":"Blackall","sequence":"first","affiliation":[{"name":"Department of Pathology Saint Louis University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shephali","family":"Wulff","sequence":"additional","affiliation":[{"name":"SSM Health Saint Joseph Hospital  Saint Charles Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Roettger","sequence":"additional","affiliation":[{"name":"SSM\u2010STL Pharmacy  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Jacobs","sequence":"additional","affiliation":[{"name":"SSM\u2010STL Pharmacy  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lacasse","sequence":"additional","affiliation":[{"name":"SSM Health Saint Mary's Hospital  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manokiran","family":"Patri","sequence":"additional","affiliation":[{"name":"SSM Health DePaul Hospital  Bridgeton Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Zinser","sequence":"additional","affiliation":[{"name":"SSM Health DePaul Hospital  Bridgeton Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Pherez","sequence":"additional","affiliation":[{"name":"SSM Health Saint Clare Hospital  Fenton Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafar","family":"Jamkhana","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saint Louis University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon E.","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saint Louis University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Smith","sequence":"additional","affiliation":[{"name":"SSM\u2010STL Laboratory  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-9905","authenticated-orcid":false,"given":"Ruchika","family":"Goel","sequence":"additional","affiliation":[{"name":"Mississippi Valley Regional Blood Center  Springfield Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Katz","sequence":"additional","affiliation":[{"name":"Mississippi Valley Regional Blood Center  Springfield Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0695-z"},{"key":"e_1_2_8_3_1","unstructured":"Centers for Disease Control and Prevention. Coronavirus disease 2019 (COVID\u201019) situation summary.https:\/\/www.cdc.gov\/coronavirus\/2019\u2010ncov\/cases\u2010updates\/summary.html. Accessed April 20 2020."},{"key":"e_1_2_8_4_1","unstructured":"Johns Hopkins University and Medicine. New cases of COVID\u201019 in world countries.https:\/\/coronavirus.jhu.edu\/data\/new-cases. Accessed May 10 2020."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104854"},{"key":"e_1_2_8_6_1","first-page":"1","article-title":"COVID\u201019, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics","volume":"18","author":"Dhama K","year":"2020","journal-title":"Hum Vaccin Immunother"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.04.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511812"},{"key":"e_1_2_8_9_1","unstructured":"Mayo Clinic. COVID\u201019 expanded access program.https:\/\/www.uscovidplasma.org\/. 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