{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:13:25Z","timestamp":1782274405128,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Background<\/jats:title><jats:sec><jats:label\/><jats:p>Fatigue is a reported symptom of iron depletion, but studies in blood donors show no conclusive link. We conducted an observational analysis of data from the STRIDE randomized trial to evaluate association of iron status with self\u2010reported fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Three blood centers randomly assigned 692 frequent donors to education or iron supplementation treatments. Biomarkers for iron status were measured during 20 to 24\u2009months of follow\u2010up. A fatigue score was derived from an 11\u2010item questionnaire at baseline and final visits, and associations between iron status and fatigue were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Final lab and questionnaire data were evaluable from 337 subjects. At baseline, female sex, older age, and anemia were associated with fatigue, but iron status was not. Mean (\u00b1SD) fatigue score change was 0.0 (\u00b10.5). Mean (\u00b1SD) increase in iron stores was 1.0 (\u00b13.5) mg\/kg, but changes in body iron stores were not associated with fatigue score changes (0.01 per mg\/kg; 95% CI, \u22120.01 to 0.02) or with fatigue (RR, 1.01; 95% CI, 0.99 to 1.04). The only factor associated with fatigue score changes was baseline fatigue (0.36; 95% CI, 0.25 to 0.48).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among high\u2010frequency donors, neither iron status at baseline nor changes in iron status predicted fatigue during follow\u2010up, with improvements limited to those with higher levels of baseline fatigue. Assessment of the association between iron and fatigue in blood donors benefits from careful consideration of study design and the study population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16095","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T02:32:22Z","timestamp":1601001142000},"page":"124-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Iron status and self\u2010reported fatigue in blood donors"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9008-9154","authenticated-orcid":false,"given":"Bryan R.","family":"Spencer","sequence":"first","affiliation":[{"name":"American Red Cross, Scientific Affairs  Dedham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"},{"name":"Department of Global Health Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Wise","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritchard G.","family":"Cable","sequence":"additional","affiliation":[{"name":"American Red Cross, Scientific Affairs  Dedham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3740-0318","authenticated-orcid":false,"given":"Alan E.","family":"Mast","sequence":"additional","affiliation":[{"name":"Blood Research Institute, Versiti  Milwaukee Wisconsin USA"},{"name":"Department of Cell Biology, Neurobiology and Anatomy Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"S1","article-title":"Slowing decline in blood collection and transfusion in the United States \u2010 2017","volume":"60","author":"Jones JM","year":"2020","journal-title":"Transfusion"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.441.441"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03310450030018"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01427.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03810.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00368.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13085"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12210"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13469"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10245"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2007.08.019"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3071"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03401.x"},{"key":"e_1_2_7_16_1","first-page":"1","article-title":"Recommendations to prevent and control iron deficiency in the United States","volume":"47","author":"Centers for Disease Control and Prevention","year":"1998","journal-title":"Morb Mortal Wkly Rep"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000409"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13659"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2011.04.007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.2.676S"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-346304"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24461"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-52-2-378"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7399.1124"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03055.x"},{"key":"e_1_2_7_27_1","unstructured":"AABB.Full length donor history questionnaire v2.0.http:\/\/www.aabb.org\/tm\/questionnaires\/Pages\/dhqaabb.aspx. 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