{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:22:27Z","timestamp":1788348147902,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["ZIA CL002128"],"award-info":[{"award-number":["ZIA CL002128"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Scianna (SC) blood group system comprises seven antigens. They reside on the erythroblast membrane\u2010associated glycoprotein (ERMAP). The <jats:italic>ERMAP<\/jats:italic> and <jats:italic>RHCE<\/jats:italic> genes are juxtaposed to each other on chromosome 1. We report a novel SC antigen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Blood samples came from a patient and his two sisters in Saudi Arabia. To investigate the antibody specificity we used the column agglutination technique and soluble recombinant ERMAP protein. The significance of anti\u2010SCAR was evaluated by the transfusion history and a monocyte monolayer assay. We determined the genomic sequence of <jats:italic>ERMAP<\/jats:italic> and <jats:italic>RHCE<\/jats:italic> genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient\u02bcs serum showed an antibody of titer 8 against a high\u2010prevalence antigen. The soluble recombinant ERMAP protein inhibited the antibody. The propositus genotyped homozygous for an <jats:italic>ERMAP:c.424C&gt;G<\/jats:italic> variant, for which his sisters were heterozygous. The <jats:italic>c.424C&gt;G<\/jats:italic> variant occurred in the <jats:italic>SC*01<\/jats:italic> allele in one haplotype with the <jats:italic>RHCE*03<\/jats:italic> (<jats:italic>RHCE*cE<\/jats:italic>) allele. No signs of hemolysis occurred following an incompatible blood transfusion. The monocyte monolayer assay was negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We characterized a high\u2010prevalence antigen, with the proposed name \u201cSCAR,\u201d which is the eighth antigen of the Scianna blood group system (proposed designation 013.008). Individuals homozygous for ERMAP:p.(Gln142Glu) protein variant can produce anti\u2010SCAR. Although we did not observe any sign of hemolysis at this time, the anti\u2010SCAR prompted a change of the treatment regimen. A review of the known reports indicated that all SC alloantibodies of sufficient titer should be considered capable of causing hemolysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16152","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T10:09:31Z","timestamp":1603534171000},"page":"246-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>SCAR<\/scp>: The high\u2010prevalence antigen 013.008 in the <scp>Scianna<\/scp> blood group system"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-0815","authenticated-orcid":false,"given":"Kshitij","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine NIH Clinical Center, National Institutes of Health  Bethesda Maryland 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