{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:57:15Z","timestamp":1760147835752,"version":"3.40.5"},"reference-count":4,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Plasma transfusion is a critical treatment in managing bleeding patients. In an effort to make plasma immediately available in spite of the limited amount of AB plasma, providers have begun using A plasma in life\u2010threatening emergencies. As this practice becomes widely adopted it is important to evaluate safety. Hemolytic transfusions reactions are underreported, and hemolysis may be subclinical.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>A retrospective study was performed at the University of Florida\/Shands Hospital of B and AB patients who received 1\u2009unit or more of A plasma. Patient charts were reviewed and data collected included age; sex; mortality; intensive care unit (ICU) length of stay; and laboratory tests used in identifying hemolysis including direct antiglobulin test, lactate dehydrogenase, haptoglobin, indirect bilirubin, aspartate aminotransferase, urinalysis, hemoglobin, and hematocrit. The primary end points of the study were immune mediated hemolysis, mortality, and length of ICU stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010three patients were identified as eligible for the study. One patient suffered a delayed hemolytic transfusion reaction determined to be due to an anti\u2010Jk<jats:sup>a<\/jats:sup>. No evidence of hemolysis due to ABO\u2010incompatible plasma transfusion was identified. The volume of A plasma transfused was found to be weakly related to mortality and ICU stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No evidence of ABO immune\u2010mediated hemolysis was observed in the patient population. The results of the study support the safety of A plasma transfusion in B and AB patients. We hypothesize the relationship observed between A plasma volume and mortality\/ICU stay may be from collinearity with disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16170","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T12:23:18Z","timestamp":1605961398000},"page":"375-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of <scp>A<\/scp> plasma for incompatible patients"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-7199","authenticated-orcid":false,"given":"Gregory","family":"Olsen","sequence":"first","affiliation":[{"name":"Department of Pathology, Laboratory Medicine, and Immunology University of Florida College of Medicine  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Passwater","sequence":"additional","affiliation":[{"name":"Blood Bank Laboratory UF Health Shands Hospital  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Huggins","sequence":"additional","affiliation":[{"name":"Blood Bank Laboratory UF Health Shands Hospital  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Mukhtar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Laboratory Medicine, and Immunology University of Florida College of Medicine  Gainesville Florida"},{"name":"Blood Bank Laboratory UF Health Shands Hospital  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Department of Pathology, Laboratory Medicine, and Immunology University of Florida College of Medicine  Gainesville Florida"},{"name":"Blood Bank Laboratory UF Health Shands Hospital  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamasurg.387"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14139"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001532"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000945"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T16:00:53Z","timestamp":1693670453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,21]]},"references-count":4,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/trf.16170"],"URL":"https:\/\/doi.org\/10.1111\/trf.16170","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2020,11,21]]},"assertion":[{"value":"2020-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}