{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:34:06Z","timestamp":1789072446119,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Irradiation of cellular blood components is recommended for patients at risk of transfusion\u2010associated graft\u2010vs\u2010host disease (TA\u2010GvHD). Prestorage leucodepletion (LD) of blood components is standard in the UK since 1999.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Analysis of 10\u2009years' reports from UK national hemovigilance scheme, Serious Hazards of Transfusion (2010\u20102019), where patients failed to receive irradiated components when indicated according to British Society for Haematology guidelines (2011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 956 incidents of failure to receive irradiated components all due to errors. One hundred and seventy two incidents were excluded from analysis, 125 of 172 (72.7%) because of missing essential information. No cases of TA\u2010GvHD were reported in this cohort. The 784 patients received 2809 components (number unknown for 67 incidents). Most failures occurred in patients treated with purine analogues (365) or alemtuzumab (69), or with a history of Hodgkin lymphoma (HL) (192). Together these make up 626 of 784 (79.9%). Poor communication is an important cause of errors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Leucodepletion appears to reduce the risk for TA\u2010GvHD. None of 12 cases of TA\u2010GvHD reported to SHOT prior to introduction of LD occurred in patients with conditions recommended for irradiated components by current guidelines. Irradiation indefinitely for all stages of HL is not based on good evidence and is a difficult guideline to follow. Further research on long\u2010term immune function in HL is required. Variation between different national guidelines reflects the very limited evidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16189","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T12:25:35Z","timestamp":1605961535000},"page":"385-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Missed irradiation of cellular blood components for vulnerable patients: Insights from 10\u2009years of <scp>SHOT<\/scp> data"],"prefix":"10.1111","volume":"61","author":[{"given":"Johnathon","family":"Elliot","sequence":"first","affiliation":[{"name":"Serious Hazards of Transfusion Office Manchester Blood Center  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruthi","family":"Narayan","sequence":"additional","affiliation":[{"name":"Serious Hazards of Transfusion Office Manchester Blood Center  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbi","family":"Poles","sequence":"additional","affiliation":[{"name":"Serious Hazards of Transfusion Office Manchester Blood Center  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Tuckley","sequence":"additional","affiliation":[{"name":"Serious Hazards of Transfusion Office Manchester Blood Center  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-7862","authenticated-orcid":false,"given":"Paula H. B.","family":"Bolton\u2010Maggs","sequence":"additional","affiliation":[{"name":"Serious Hazards of Transfusion Office Manchester Blood Center  UK"},{"name":"Faculty of Biology, Medicine and Health University of Manchester  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196510282731803"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199002013220507"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08444.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.1996.tb00078.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-620872"},{"key":"e_1_2_7_8_1","unstructured":"Blood Safety and Quality Regulations 2005 (as amended).2005.https:\/\/www.health-ni.gov.uk\/articles\/blood-safety-and-quality-regulations-2005-amended\/. Accessed August 23 2020."},{"key":"e_1_2_7_9_1","unstructured":"NarayanS PolesD the SHOT Steering Group.The 2019 Annual SHOT Report (2020).https:\/\/www.shotuk.org\/shot-reports\/report-summary-and-supplement-2019\/. Accessed August 23 2020."},{"key":"e_1_2_7_10_1","unstructured":"Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee.Leucocyte depletion. 2015.https:\/\/www.transfusionguidelinesorg\/red-book\/chapter-7-specifications-for-blood-components\/7-1-leucocyte-depletion. Accessed August 20 2020."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03782.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12481"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.10.2096.2096"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901201)66:11<2346::AID-CNCR2820661116>3.0.CO;2-T"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-5-595"},{"issue":"2","key":"e_1_2_7_16_1","first-page":"114","article-title":"Impact of Hodgkin\u02bcs disease upon the immune system","volume":"7","author":"Twomey JJ","year":"1980","journal-title":"Semin Oncol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2018.7724"},{"key":"e_1_2_7_19_1","unstructured":"Australian and New Zealand Society of Blood Transfusion Ltd.Guidelines for prevention of transfusion\u2010associated graft\u2010versus\u2010host disease 2011.https:\/\/anzsbt.org.au\/wp-content\/uploads\/2018\/06\/PreventionofTA-GVHD.pdf. Accessed August 23 2020."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0167-CP"},{"key":"e_1_2_7_21_1","unstructured":"Richtlijn Bloedtransfusiebeleid \u2013 deel 3 Autorisatiefase juli 2020.https:\/\/nvbtransfusie.nl\/wp-content\/uploads\/2019\/07\/Richtlijn-Bloedtransfusiebeleid-deel-3_ter-autorisatie.pdf. Accessed August 23 2020."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2240-z"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14233"},{"issue":"1","key":"e_1_2_7_24_1","first-page":"P\u2010627","article-title":"Challenges in the appropriate use of irradiated blood components at a large UK haemato\u2010oncology centre","volume":"112","author":"Booth C","year":"2017","journal-title":"Vox Sang"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197402142900703"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16189","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16189","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T15:58:40Z","timestamp":1693670320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,21]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/trf.16189"],"URL":"https:\/\/doi.org\/10.1111\/trf.16189","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,21]]},"assertion":[{"value":"2020-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}