{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:01:28Z","timestamp":1782446488829,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) is a common indication for autologous stem cell transplantation (auto\u2010SCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>This prospective noninterventional study aimed to evaluate the impact of mobilization characteristics and graft cellular content on hematologic recovery and outcome after auto\u2010SCT among 68 patients with DLBCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Better mobilization capacity as manifested by blood CD34<jats:sup>+<\/jats:sup> cell count &gt;32\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/L and CD34<jats:sup>+<\/jats:sup> cell yield of the first apheresis &gt;2.75\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg correlated with faster neutrophil (<jats:italic>P<\/jats:italic> = .005 and <jats:italic>P<\/jats:italic> = .017) and platelet (<jats:italic>P<\/jats:italic> = .002 and <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) recovery. A higher number of infused CD34<jats:sup>+<\/jats:sup> cells (&gt;\u20092.65\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg) was associated with better 5\u2010year overall survival (OS; 95% <jats:italic>vs<\/jats:italic> 67%, <jats:italic>P<\/jats:italic> = .012). The graft CD34<jats:sup>+<\/jats:sup>CD133<jats:sup>+<\/jats:sup>CD38<jats:sup>\u2212<\/jats:sup> cell count &gt;0.07\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg was predictive of better 5\u2010year OS (87% <jats:italic>vs<\/jats:italic> 63%; <jats:italic>P<\/jats:italic> = .008) and higher graft CD3<jats:sup>+<\/jats:sup> cell count (&gt;23.1\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg) correlated also with better 5\u2010year OS (80% vs 40%, <jats:italic>P<\/jats:italic> = .008). In multivariate analysis only disease status of CR I at auto\u2010SCT was associated with better progression\u2010free survival (<jats:italic>P<\/jats:italic> = .014) and OS (<jats:italic>P<\/jats:italic> = .039).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The mobilization capacity of CD34<jats:sup>+<\/jats:sup> cells impacted on early hematologic recovery in patients with DLBCL after auto\u2010SCT. Higher graft CD34<jats:sup>+<\/jats:sup> cell count and both CD34<jats:sup>+<\/jats:sup>CD133<jats:sup>+<\/jats:sup>CD38<jats:sup>\u2212<\/jats:sup> and CD3<jats:sup>+<\/jats:sup> cells were also associated with better OS. The effect of optimal graft cellular composition on outcome in DLBCL should be evaluated in a randomized study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16198","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T15:39:25Z","timestamp":1606491565000},"page":"516-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mobilization characteristics, blood graft composition, and outcome in diffuse large <scp>B\u2010cell<\/scp> lymphoma after <scp>autologous<\/scp> stem cell transplantation: Results from the prospective multicenter <scp>GOA<\/scp> study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-2582","authenticated-orcid":false,"given":"Anu","family":"Partanen","sequence":"first","affiliation":[{"name":"Department of Medicine Kuopio University Hospital  Kuopio 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