{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:18:12Z","timestamp":1790363892002,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>As sex between men is a major route of human immunodeficiency virus (HIV) infection in most western countries, restrictive deferral rules for blood donation have largely been implemented regarding men having sex with men (MSM). Here, we sought here to assign unreported HIV risk factors in blood donors (BDs) and reevaluated the MSM\u2010associated fraction of HIV transfusion residual risk (%RR<jats:sub>MSM<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We applied a genetic distance\u2010based approach to infer an HIV transmission network for 384 HIV sequences from French BDs and 1337 HIV sequences from individuals with known risk factors (ANRS PRIMO primary HIV infection cohort). We validated the possibility of assigning a risk factor according to clustering using assortative mixing. Finally, we recalculated the %RR<jats:sub>MSM<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 81 of 284 (28.5%) male and 5 of 100 (5%) female BDs belonged to a cluster; 72 (88.9%) of the 81 male BDs belonged to MSM clusters. After cluster correction, 8 of 67 (11.9%), 4 of 21 (19.0%), and 19 of 88 (21.6%) HIV\u2010positive (HIV+) male BDs with heterosexual, other, or unknown risk factors could be reclassified as MSM, accounting for 10.9% of the total HIV+ male BDs. Overall, 139 of 284 HIV+ male donors (48.9%) could be considered MSM between 2000 and 2016 in France. Between 2005 and 2016, the %RR<jats:sub>MSM<\/jats:sub> increase varied from 0 to 19%, without differing significantly from the %RR<jats:sub>MSM<\/jats:sub> before reclassification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Network inference can be used to complement declaration data on risk factors for HIV infection in BDs. This approach, complementary to behavioral studies, is a valuable tool to evaluate the effect of changes in deferral criteria on BD compliance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16290","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T01:12:19Z","timestamp":1613783539000},"page":"1191-1201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>HIV<\/scp> transmission network analysis allows identifying unreported risk factors in <scp>HIV<\/scp>\u2010positive blood donors in <scp>France<\/scp>"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8540-2196","authenticated-orcid":false,"given":"Pierre","family":"Cappy","sequence":"first","affiliation":[{"name":"D\u00e9partement des Agents Transmissibles par le Sang, CNR Risques Infectieux Transfusionnels Institut National de la Transfusion Sanguine (INTS)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Chaillon","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-776X","authenticated-orcid":false,"given":"Josiane","family":"Pillonel","sequence":"additional","affiliation":[{"name":"D\u00e9partement des maladies infectieuses Sant\u00e9 publique France  Saint\u2010Maurice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Essat","sequence":"additional","affiliation":[{"name":"INSERM CESP U1018 Universit\u00e9 Paris Sud, Universit\u00e9 Paris Saclay  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Laure","family":"Chaix","sequence":"additional","affiliation":[{"name":"Service de Virologie, CNR VIH, H\u00f4pital Saint\u2010Louis, APHP \u2010 INSERM U944 Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Meyer","sequence":"additional","affiliation":[{"name":"INSERM CESP U1018 Universit\u00e9 Paris Sud, Universit\u00e9 Paris Saclay  Le Kremlin\u2010Bic\u00eatre France"},{"name":"Service de Sant\u00e9 Publique H\u00f4pital Bic\u00eatre, APHP  Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Barin","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, Laboratoire associ\u00e9 au CNR VIH, CHRU de Tours \u2010 INSERM U1259 Universit\u00e9 de Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Tiberghien","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang  La Plaine St Denis France"},{"name":"UMR 1098 INSERM Universit\u00e9 de Franche\u2010Comt\u00e9, Etablissement Fran\u00e7ais du Sang  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syria","family":"Laperche","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Agents Transmissibles par le Sang, CNR Risques Infectieux Transfusionnels Institut National de la Transfusion Sanguine (INTS)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15203"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2009.00969.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12554"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14187"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12144"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13298"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12951"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1700740"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12623"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12975"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098443"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu560"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001325"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-017-0339-4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001856"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy044"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031695"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006000"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.67.026126"},{"key":"e_1_2_8_22_1","unstructured":"French 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