{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:57:49Z","timestamp":1791849469966,"version":"4.3.4"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe blood donor adverse events are rare, but due to their rarity studying them can be difficult. To get an accurate estimate of their frequency and rate in the donor population it may be necessary to combine donation data across countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>International blood collection organizations (BCOs) provided data on rare\/severe donor reactions as well as denominator information for their donor populations from 2015 to 2017. Donor reactions were classified using standardized definitions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BCOs from six countries provided reaction data for more than 22 million donations. A total of 480 rare reactions were reported of which 76.7% were imputed as definite and 11% probable. Rates of rare reactions were higher in females and first\u2010time donors. Systemic rare reactions were the most common reaction type, accounting for over three quarters of reactions reported. Of systemic reactions, vasovagal reactions with loss of consciousness and injury or off\u2010site (n\u00a0=\u00a0350) made up the majority and occurred 1.53 per 100,000 donations. For the 22.3% that were localized reactions, the majority of these were cellulitis (n\u00a0=\u00a071, 0.31 per 100,000 donations) followed by deep venous thrombosis (n\u00a0=\u00a021, 0.09 per 100,000 donations).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pulling together data from multiple BCOs across countries allows for a better understanding of rare reactions, such as vasovagal reaction with injury or cellulitis, and for generating a reliable incidence rate for air embolism or compartment syndrome. However, gaps remain due to missing elements such as unknown donor status or location of reaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.16333","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T03:28:21Z","timestamp":1614914901000},"page":"1780-1788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Frequency of rare, serious donor reactions: International perspective"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5313-0376","authenticated-orcid":false,"given":"Pampee","family":"Young","sequence":"first","affiliation":[{"name":"American Red Cross  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Crowder","sequence":"additional","affiliation":[{"name":"American Red Cross  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7955-3115","authenticated-orcid":false,"given":"Whitney","family":"Steele","sequence":"additional","affiliation":[{"name":"American Red Cross  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Irving","sequence":"additional","affiliation":[{"name":"Australian Red Cross Lifeblood  Kelvin Grove Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Pink","sequence":"additional","affiliation":[{"name":"Australian Red Cross Lifeblood  Kelvin Grove Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Mauro","family":"Kutner","sequence":"additional","affiliation":[{"name":"Cell Therapy and Hemotherapy Department Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Hitomi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Cell Therapy and Hemotherapy Department Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1309-9770","authenticated-orcid":false,"given":"Nancy","family":"Van Buren","sequence":"additional","affiliation":[{"name":"Memorial Blood Centers, New York Blood Center Enterprises  Saint Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas William","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Welsh Blood Service  Ynysmaerdy UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-2480","authenticated-orcid":false,"given":"Merlyn","family":"Sayers","sequence":"additional","affiliation":[{"name":"Carter Blood Care  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramir Moreno","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Blood Services Group, Health Sciences Authority  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"van den Hurk","sequence":"additional","affiliation":[{"name":"Sanquin  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-9911","authenticated-orcid":false,"given":"Johanna","family":"Wiersum\u2010Osselton","sequence":"additional","affiliation":[{"name":"Sanquin  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2270-4821","authenticated-orcid":false,"given":"Beth","family":"Shaz","sequence":"additional","affiliation":[{"name":"Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Biomedical Excellence for Safer Transfusion (BEST) Collaborative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"RajbhandaryS StubbsJR LandKJ Whitaker BI (eds). AABB Donor Hemovigilance Report: 2012\u20132014 on behalf of the AABB US Donor Hemovigilance Working Group AABB Press Bethesda 2016."},{"key":"e_1_2_7_3_1","unstructured":"US Food & Drug Administration.Blood & blood products [monograph on the Internet]. Available from:https:\/\/www.fda.gov\/biologicsbloodvaccines\/bloodbloodproducts\/"},{"key":"e_1_2_7_4_1","first-page":"143","article-title":"Adverse reactions during voluntary donation of blood and\/or blood components. A statistical\u2010epidemiological study","volume":"5","author":"Crocco A","year":"2007","journal-title":"Blood Transfus"},{"key":"e_1_2_7_5_1","volume-title":"AABB donor hemovigilance 2012\u20132017","author":"AABB Hemovigilance System\u2010DonorHART","year":"2019"},{"key":"e_1_2_7_6_1","unstructured":"GoldmanM LandK RobillardP TomasuloP Wiersum\u2010OsseltonJfor the Working Group on Donor Vigilance of the International Society of Blood Transfusion Working Party on Haemovigilance. Standard for surveillance of complications related to blood donation. AABB ISBT IHN.2014."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12488"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03439.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00368.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15830"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16333","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T08:20:45Z","timestamp":1693383645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/trf.16333"],"URL":"https:\/\/doi.org\/10.1111\/trf.16333","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,5]]},"assertion":[{"value":"2020-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}