{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:29:52Z","timestamp":1773930592170,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["09\u2010069412"],"award-info":[{"award-number":["09\u2010069412"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blood donors report better health\u2010related quality of life (HRQL) than non\u2010donors. Likewise, donors reporting good health are less likely to stop donating and have a higher donation frequency. This is evidence of the healthy donor effect (HDE). This study is the first to investigate the impact of HRQL and depressive symptoms on subsequent donor career.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Prospective cohort study includes 102,065 participants from the Danish Blood Donor Study applying the 12\u2010item short\u2010form health survey (SF\u201012) measuring a mental (MCS) and a physical component score (PCS) and the Major Depression Inventory (MDI). Poisson and Cox regression models were used to assess the effect of SF\u201012 and MDI scores on donation frequency and donor cessation. Higher MCS\/PCS scores indicate good HRQL, while higher MDI score indicates higher experience of depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For both sexes, MCS was positively correlated with donation frequency for up to 5\u2009years, and similarly for PCS among women. A negative correlation between MDI score and donation frequency in the year following assessment was observed only among men. No correlation was observed among women. An increase in both MCS and PCS was associated with a lower risk of donation cessation in both sexes, while an increase in MDI score was only associated with an increased risk of donation cessation in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MCS, PCS, and MDI score affect donor career. Thus, adjusting for donation frequency may reduce HDE\u2010bias in donor health research. However, because of the small effect sizes, other ways of quantifying HDE may be beneficial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16336","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T11:03:52Z","timestamp":1614683032000},"page":"1479-1488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of health\u2010related quality of life and depressive symptoms on blood donor career\u2014Results from the <scp>Danish<\/scp> blood donor study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4856-496X","authenticated-orcid":false,"given":"Maria","family":"Didriksen","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise W.","family":"Th\u00f8rner","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margit A. H.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristoffer","family":"Burgdorf","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus 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