{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:45:07Z","timestamp":1784760307118,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) has a variable clinical course with significant mortality. Early reports suggested higher rates of SARS\u2010CoV\u20102 infection in patients with type A blood and enrichment of type A individuals among COVID\u201019 mortalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>The study includes all patients hospitalized or with an emergency department (ED) visit who were tested for SARS\u2010CoV\u20102 between March 10, 2020 and June 8, 2020 and had a positive test result by nucleic acid test (NAT) performed on a nasopharyngeal swab specimen. A total of 4968 patients met the study inclusion criteria, with a subsequent 23.1% (n = 1146\/4968) all\u2010cause mortality rate in the study cohort. To estimate overall risk by ABO type and account for the competing risks of in\u2010hospital mortality and discharge, we calculated the cumulative incidence function (CIF) for each event. Cause\u2010specific hazard ratios (csHRs) for in\u2010hospital mortality and discharge were analyzed using multivariable Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Type A blood was associated with the increased cause\u2010specific hazard of death among COVID\u201019 patients compared to type O (HR = 1.17, 1.02\u20131.33, <jats:italic>p<\/jats:italic> =\u2009.02) and type B (HR = 1.32,1.10\u20131.58, <jats:italic>p<\/jats:italic> =\u2009.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study shows that ABO histo\u2010blood group type is associated with the risk of in\u2010hospital death in COVID\u201019 patients, warranting additional inquiry. Elucidating the mechanism behind this association may reveal insights into the susceptibility and\/or immunity to SARS\u2010CoV\u20102.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16339","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T08:31:40Z","timestamp":1614933100000},"page":"1064-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["<scp>ABO<\/scp> blood type association with <scp>SARS\u2010CoV<\/scp>\u20102 infection mortality: A single\u2010center population in <scp>New York City<\/scp>"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0202-7058","authenticated-orcid":false,"given":"James","family":"Szymanski","sequence":"first","affiliation":[{"name":"Department of Pathology Montefiore Medical Center and Albert Einstein College of Medicine  Bronx New York 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