{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:20:12Z","timestamp":1791199212789,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of pre\u2212\/post\u2010exposure prophylaxis (PrEP\/PEP) may interfere with routine HIV screening. As a result, blood services worldwide have adopted a variety of deferral policies to mitigate increased residual risk. In this study, we evaluated the operational impact of modifying the donor health questionnaire (DHQ) to include explicit questions to assess PrEP\/PEP exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We conducted a retrospective study between June 2019 and October 2020 of all blood donors attempting to donate at Canadian Blood Services. Sixteen\u2010months post\u2010implementation, we summarized self\u2010reported PrEP\/PEP rates and their indications for use. We also assessed deferral rates and the sensitivity of using existing risk questions to defer people exposed to PrEP\/PEP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1,122,075 donations, 89 people (eight per 100,000 donations) reported PrEP (64%)\/PEP (34%) use in the last 4 months. People exposed to PrEP were more likely to be men (94%) and taking PrEP for lifestyle reasons (87%). In contrast, indications for PEP use included occupational exposure (50%) and sexual assault (27%). Most donors who answered affirmatively to PrEP\/PEP exposure were deferred (96%). If potential donors were not directly asked about their PrEP\/PEP use, the majority would not have been deferred for any other reasons (PrEP 32\/57 (56%) and PEP 15\/30 (50%)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Not all blood services have adopted direct questions to identify PrEP\/PEP exposure; some rely on existing DHQ questions. In Canada, despite DHQ questions such as medication use in the last 3\u2010days, more than half of people exposed to PrEP\/PEP would not have been identified and deferred.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16349","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T10:54:40Z","timestamp":1615892080000},"page":"1684-1689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of a pre\u2010exposure prophylaxis (PrEP)\/post\u2010exposure prophylaxis (PEP) deferral policy among blood donors"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0224-379X","authenticated-orcid":false,"given":"Sahar","family":"Saeed","sequence":"first","affiliation":[{"name":"Epidemiology and Surveillance Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-9952","authenticated-orcid":false,"given":"Mindy","family":"Goldman","sequence":"additional","affiliation":[{"name":"Epidemiology and Surveillance Canadian Blood Services  Ottawa Ontario Canada"},{"name":"Department of Pathology and Laboratory Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samra","family":"Uzicanin","sequence":"additional","affiliation":[{"name":"Epidemiology and Surveillance Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila F.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Epidemiology and Surveillance Canadian Blood Services  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-833996"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12516"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006890"},{"key":"e_1_2_7_5_1","unstructured":"World Health Organization.Pre\u2010exposure prophylaxis recommendation. [cited Dec 2 2020]. Available from:www.who.int\/hiv\/topics\/prep\/en\/"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170494"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw365"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001577"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.17134"},{"key":"e_1_2_7_10_1","unstructured":"Australian Red Cross Lifeblood. [cited Dec 4 2020]. Available from:https:\/\/www.donateblood.com.au\/eligibility#undefined."},{"key":"e_1_2_7_11_1","unstructured":"Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee. Pre\u2010 and post\u2010exposure prophylaxis for HIV prevention. [cited Dec 4 2020]. Available from:https:\/\/www.transfusionguidelines.org\/dsg\/wb\/guidelines\/pre-and-post-exposure-prophylaxis-for-hiv"},{"key":"e_1_2_7_12_1","unstructured":"AABB Donor Health Questionnaire. [2020 Dec 2]. Available from:https:\/\/www.aabb.org\/news-resources\/resources\/donor-history-questionnaires\/blood-donor-history-questionnaires."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13011"},{"key":"e_1_2_7_14_1","unstructured":"European Blood Alliance.2019 Annual Report. [2020 Dec 2]. Available from:https:\/\/europeanbloodalliance.eu\/wp-content\/uploads\/2020\/06\/EBA_Annual_Report_2019_DIGITAL_compressed.pdf."},{"key":"e_1_2_7_15_1","unstructured":"Sanquin. [2020 Dec 4]. Available from:https:\/\/www.sanquin.nl\/en\/become-a-donor\/what-happens-after-i-register\/is-your-blood-safe."},{"key":"e_1_2_7_16_1","unstructured":"BC Centre for Excellence in HIV\/AIDS.HIV pre\u2010exposure prophylaxis (PrEP). [2020 Dec 2]. Available from:http:\/\/www.cfenet.ubc.ca\/hiv-pre-exposure-prophylaxis-prep."},{"key":"e_1_2_7_17_1","unstructured":"CATIE.PrEP access coverage. [2020 Dec 2]. Available from:https:\/\/hivclinic.ca\/wp-content\/uploads\/2019\/07\/ARV-Coverage_July-2019.pdf."},{"key":"e_1_2_7_18_1","first-page":"89","article-title":"Trends in HIV pre\u2010exposure prophylaxis uptake in Ontario, Canada, and impact of policy changes: a population\u2010based analysis of projected pharmacy data (2015\u20102018)","volume":"112","year":"2021","journal-title":"Canadian Journal of Public Health = Revue Canadienne de Sante Publique"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T12:23:08Z","timestamp":1693398188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,16]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/trf.16349"],"URL":"https:\/\/doi.org\/10.1111\/trf.16349","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,16]]},"assertion":[{"value":"2020-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}