{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:43:24Z","timestamp":1776948204862,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are several strategies to reduce donor reactions. We report donor participation and reaction rates before and after implementing multiple measures at Canadian Blood Services.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design and methods<\/jats:title><jats:p>We introduced a structured program of 500\u2009mL of water and a salty snack pre\u2010donation and applied muscle tension (AMT) during donation. Donors were not deferred for out of range blood pressure (BP); however, BP was measured in first time donors. Time on the donation chair post\u2010donation was decreased from 5 to 2\u2009min for repeat donors. We assessed participation rates using our quarterly survey of 10,000 recent donors. We extracted vasovagal reactions with loss of consciousness (LOC) from our operational database and compared pre\u2010implementation (Oct 12,018\u2010March 31,2019) and post\u2010implementation (Oct 12,019\u2010March 31,2020) periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Survey response rates varied from 11% to 16%. The percentage of donors who drank the water and ate the salty snack increased from 58% to 82% and 44% to 70% over 4 quarters; those performing AMT increased from 24% to 41%. Reactions decreased from 19.07 per 10,000 (744 reactions in 390,123 donations) to 14.04 per 10,000 (537 in 382,382 donations) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). No first\u2010time donors with high BP (n\u00a0=\u00a0684) but 5 with low BP (n\u00a0=\u00a0718) had reactions, CI were very large.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Achieving optimal participation was challenging. After implementation of a donor wellness initiative based on best practice, rates of vasovagal reactions with LOC decreased by 25%. A larger dataset is necessary to assess the safety contribution of BP deferrals when other mitigation measures are in place.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16375","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T22:45:24Z","timestamp":1619045124000},"page":"1764-1771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Implementation of measures to reduce vasovagal reactions: Donor participation and results"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-9952","authenticated-orcid":false,"given":"Mindy","family":"Goldman","sequence":"first","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Ottawa Ontario Canada"},{"name":"Department of Pathology and Laboratory Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samra","family":"Uzicanin","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne","family":"Marquis\u2010Boyle","sequence":"additional","affiliation":[{"name":"Supply Chain Process Management Canadian Blood Services  Saint John New Brunswick Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila F.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2011.07.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03074.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03143.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03202.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12275"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15442"},{"key":"e_1_2_7_8_1","article-title":"Vox Sanguinis international forum on mitigation strategies to prevent faint and pre\u2010faint adverse reactions in whole blood donors: Summary","author":"Goldman M","journal-title":"Vox Sang. Published online Nov 27, 2020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2014.03.332"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12772"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14934"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02381.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15701"},{"issue":"2","key":"e_1_2_7_14_1","first-page":"234A","article-title":"Water and salt intake before blood donation reduces vasovagal reactions in both genders, all age groups for whole blood donors","volume":"58","author":"Robillard P","year":"2018","journal-title":"Transfusion"},{"issue":"1","key":"e_1_2_7_15_1","first-page":"39","article-title":"Trends in vasovagal reactions in blood donors and impact of provincial mitigation interventions: A 4\u2010year retrospective study with interrupted time\u2010series analysis","volume":"115","author":"Lewin A","year":"2020","journal-title":"Vox Sang"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13716"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14940"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15065"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12002"},{"key":"e_1_2_7_20_1","unstructured":"AABB Blood Products Advisory Committee 2009.Statement on blood pressure and pulse as blood donor eligibility criteria November 17.http:\/\/www.aabb.org\/advocacy\/statements\/Documents\/statement111709.pdf#search=Blood%20Products%20Advisory%20Committee%20November%202009"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T12:20:35Z","timestamp":1693398035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,20]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/trf.16375"],"URL":"https:\/\/doi.org\/10.1111\/trf.16375","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,20]]},"assertion":[{"value":"2021-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}