{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:57:16Z","timestamp":1791640636263,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fibrinogen concentrates and cryoprecipitate are currently used for fibrinogen supplementation in bleeding patients with dysfibrinogenemia. Both products provide an abundant source of fibrinogen but take greater than 10\u00a0min to prepare for administration. Fibrinogen concentrates lack coagulation factors (i.e., factor VIII [FVIII], factor XIII [FXIII], von Willebrand factor [VWF]) important for robust hemostatic function. Cryoprecipitate products contain these factors but have short shelf lives (&lt;6\u00a0h). Pathogen reduction (PR) of cryoprecipitate would provide a shelf\u2010stable immediately available adjunct containing factors important for rescuing hemostatic dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Hemostatic adjunct study products were psoralen\u2010treated PR\u2010cryoprecipitated fibrinogen complex (PR\u2010Cryo FC), cryoprecipitate (Cryo), and fibrinogen concentrates (FibCon). PR\u2010Cryo FC and Cryo were stored for 10\u2009days at 20\u201324\u00b0C. Adjuncts were added to coagulopathies (dilutional, 3:7 whole blood [WB]:normal saline; or lytic, WB\u2009+\u200975\u2009ng\/ml tissue plasminogen activator), and hemostatic function was assessed by rotational thromboelastometry and thrombin generation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PR of cryoprecipitate did not reduce levels of FVIII, FXIII, or VWF. PR\u2010Cryo FC rescued dilutional coagulopathy similarly to Cryo, while generating significantly more thrombin than FibCon, which also rescued dilutional coagulopathy. Storage out to 10\u2009days at 20\u201324\u00b0C did not diminish the hemostatic function of PR\u2010Cryo FC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>PR\u2010Cryo FC provides similar and\/or improved hemostatic rescue compared to FibCon in dilutional coagulopathies, and this rescue ability is stable over 10\u2009days of storage. In hemorrhaging patients, where every minute delay is associated with a 5% increase in mortality, the immediate availability of PR\u2010Cryo FC has the potential to improve outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16376","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T09:32:14Z","timestamp":1616491934000},"page":"1943-1954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of pathogen reduction technology and storage duration on the ability of cryoprecipitate to rescue induced coagulopathies in vitro"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8152-9974","authenticated-orcid":false,"given":"Kimberly A.","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3756-2747","authenticated-orcid":false,"given":"Susan M.","family":"Shea","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-0541","authenticated-orcid":false,"given":"Philip C.","family":"Spinella","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamasurg.387"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004378"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.09.039"},{"issue":"2","key":"e_1_2_8_6_1","article-title":"Fibrinogen metabolic responses to trauma","volume":"17","author":"Martini WZ","year":"2009","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.10.017"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318160a57b"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30077-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-020-0291-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181271ba3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12734"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14259"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.06.005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001431"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002173"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000017219.83330.FF"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001423"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002025"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu158"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11072"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.01.055"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12417"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2009.03.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12376"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev134"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2019.05.001"},{"key":"e_1_2_8_28_1","unstructured":"Cerus Corporation Announces FDA Approval for INTERCEPT Blood System for Cryoprecipitation 2020. Available from:https:\/\/ir.cerus.com\/news-and-events\/press-releases\/press-releases-details\/2020\/Cerus-Corporation-Announces-FDA-Approval-for-INTERCEPT-Blood-System-for-Cryoprecipitation\/default.aspx."},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15157"},{"issue":"6","key":"e_1_2_8_30_1","first-page":"454","article-title":"The effect of pathogen inactivation on cryoprecipitate: A functional and quantitative evaluation","volume":"18","author":"Kamyszek RW","year":"2020","journal-title":"Blood Transfus"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12997"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001160"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.173930"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001531"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T12:21:34Z","timestamp":1693398094000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/trf.16376"],"URL":"https:\/\/doi.org\/10.1111\/trf.16376","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]},"assertion":[{"value":"2020-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}