{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T21:53:41Z","timestamp":1784152421559,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With the recent approval of COVID\u201019 vaccines, recovered COVID\u201019 subjects who are vaccinated may be ideal candidates to donate COVID\u201019 convalescent plasma (CCP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Series<\/jats:title>\n                    <jats:p>Eleven recovered COVID\u201019 patients were screened to donate CCP. All had molecularly confirmed COVID\u201019, and all but one were antibody positive by chemiluminescence immunoassay (DiaSorin) prior to vaccination. All were tested again for antibodies 11\u201321\u2009days after they were vaccinated (Pfizer\/Moderna). All showed dramatic increases (~50\u2010fold) in spike\u2010specific antibody levels and had at least a 20\u2010fold increase in the IC50 neutralizing antibody titer based on plaque reduction neutralization testing (PRNT). The spike\u2010specific antibody levels following vaccination were significantly higher than those seen in any non\u2010vaccinated COVID\u201019 subjects tested to date at our facility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Spike\u2010specific and neutralizing antibodies demonstrated dramatic increases following a single vaccination after COVID\u201019 infection, which significantly exceeded values seen with COVID\u201019 infection alone. Recovered COVID\u201019 subjects who are vaccinated may make ideal candidates for CCP donation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.16401","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T05:07:32Z","timestamp":1617858452000},"page":"2099-2106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Exponential increase in neutralizing and spike specific antibodies following vaccination of\n                    <scp>COVID<\/scp>\n                    \u201019 convalescent plasma donors"],"prefix":"10.1111","volume":"61","author":[{"given":"Molly A.","family":"Vickers","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Sariol","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Leon","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Ehlers","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron V.","family":"Locher","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry A.","family":"Dubay","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dena","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby E.","family":"Odle","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrl","family":"Holida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-5937","authenticated-orcid":false,"given":"Anna E.","family":"Merrill","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Perlman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Iowa  Iowa City Iowa"},{"name":"Department of Pediatrics University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3964-5466","authenticated-orcid":false,"given":"C. Michael","family":"Knudson","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15797"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2020.102936"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2020.8630"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102554"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2020-002554"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12973"},{"issue":"5","key":"e_1_2_6_8_1","article-title":"Infusion of convalescent plasma is associated with clinical improvement in critically ill patients with Covid\u201019: A comment","volume":"72","author":"Ruiz\u2010Arg\u00fcelles GJ","year":"2020","journal-title":"Rev Invest Clin"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10044"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1088-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2033700"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2031304"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2031893"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15842"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jalm\/jfaa125"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa753"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2020.100169"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2021.26.6.2100096"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","unstructured":"BradleyT GrundbergE SelvaranganR.Antibody responses boosted in seropositive healthcare workers after single dose of SARS\u2010CoV\u20102 mRNA vaccine. medRxiv2021.https:\/\/doi.org\/10.1101\/2021.02.03.21251078.","DOI":"10.1101\/2021.02.03.21251078"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2639-4"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2814-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa803"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16401","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T20:42:17Z","timestamp":1693341737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/trf.16401"],"URL":"https:\/\/doi.org\/10.1111\/trf.16401","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.02.02.21250836","asserted-by":"object"}]},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]},"assertion":[{"value":"2021-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}