{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:20:11Z","timestamp":1771050011411,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Convalescent plasma (CP) is an important initial treatment in pandemics and the New York (NY) metropolitan area is likely to remain a hotspot for collection and distribution of such units. This study reports characteristics of coronavirus disease 19 CP (CCP) donors and their donations to the New York Blood Center (NYBC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design and methods<\/jats:title><jats:p>All CCP data from our first day of collection on March 26th through July 7th, 2020 are included in this retrospective analysis. Donor and donation data were extracted from NYBC electronic databases. SARS\u2010CoV\u20102 antibody testing was initially performed by the NY State Department of Health, and later by NYBC using Ortho and Abbott platforms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CCP donor age and ABO distributions were consistent with reported lower COVID\u201019 susceptibility in O blood types. CCP versus whole blood donors had similar on\u2010site deferrals, but higher post\u2010donation deferral rates. CCP versus routine plasmapheresis donations had higher vasovagal reactions but similar product rejection rates. Changes in antibody (Ab) test platforms resulted in significant changes in the percent of donors regarded as antibody positive. Donor correlates with higher anti\u2010spike total Ig S\/CO ratios were Hispanic ethnicity, overweight body mass index, and longer symptom duration; and with higher anti\u2010nucleocapsid IgG S\/CO ratios were male gender, older age, Hispanic ethnicity, and fewer days between symptom onset and first donation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We identify donor characteristics not previously reported to correlate with Ab titer. Our analysis should assist with donor outreach strategies, blood center operating logistics, and recruitment of high titer donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16421","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T10:00:16Z","timestamp":1619517616000},"page":"2374-2383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characteristics of coronavirus disease 19 convalescent plasma donors and donations in the New York metropolitan area"],"prefix":"10.1111","volume":"61","author":[{"given":"Saagar","family":"Jain","sequence":"first","affiliation":[{"name":"Lindsley F. Kimball Research Institute, New York Blood Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keshav","family":"Garg","sequence":"additional","affiliation":[{"name":"Lindsley F. 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