{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:53:23Z","timestamp":1787662403649,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2017\u201001954"],"award-info":[{"award-number":["2017\u201001954"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blood donation is associated with a number of adverse events. Most of these are both uncommon and nonsevere, leading to mild discomfort for the donor at worst. However, adverse events occurring outside of the donation facility have largely not been studied. In this study, we aim to further the understanding by performing the first large\u2010scale analysis of short\u2010term risks following whole blood donation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We set up a nationwide cohort of donors who donated whole blood between 1987 and 2018. Analyses were conducted using conditional logistic regression in a self\u2010comparison design, where each donor was compared only to themselves, considering the 30\u2010day risk of 16 outcomes following whole blood donation. Outcomes included cardiac\/vascular diseases such as myocardial infarction, unspecified conditions such as fainting, accidents or external causes of injury, and death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 963,311 donors were included; of whom, 19,670 experienced at least one of the outcomes within 30\u2009days of a blood donation. For fainting and hypotonia, we observed transient 2\u2010 to 5\u2010fold risk increases on the day of donation and the subsequent 2\u20133\u2009days. Importantly, the risk increase for the most pronounced effect corresponded to less than one additional events of fainting per 200,000 blood donations. Risks of all other outcomes were either unaffected or lower than expected right after blood donation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>To conclude, we found no evidence of new or unexpected short\u2010term health effects after blood donation and confirmed that risks of hypotension\u2010related events requiring hospital care are present but small.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16445","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T05:43:32Z","timestamp":1620884612000},"page":"2347-2355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Short\u2010term health outcomes following whole blood donation: A nationwide, retrospective cohort study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-3250","authenticated-orcid":false,"given":"Fredrik","family":"Toss","sequence":"first","affiliation":[{"name":"Division of Clinical Immunology, Department of Clinical Microbiology Ume\u00e5 University  Ume\u00e5 Sweden"},{"name":"Department of Integrative Medical Biology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-1143","authenticated-orcid":false,"given":"Jingcheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Solna, Clinical Epidemiology Division Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvid","family":"Sj\u00f6lander","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2198-4745","authenticated-orcid":false,"given":"Gustaf","family":"Edgren","sequence":"additional","affiliation":[{"name":"Department of Medicine, Solna, Clinical Epidemiology Division Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Cardiology, S\u00f6dersjukhuset  Stockholm 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