{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:42:14Z","timestamp":1790883734534,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R34 HL125804"],"award-info":[{"award-number":["R34 HL125804"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Plasma is frequently administered to patients with prolonged INR prior to invasive procedures. However, there is limited evidence evaluating efficacy and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We performed a pilot trial in hospitalized patients with INR between 1.5 and 2.5 undergoing procedures conducted outside the operating room. We excluded patients undergoing procedures proximal to the central nervous system, platelet counts &lt;40,000\/\u03bcl, or congenital or acquired coagulation disorders unresponsive to plasma. We randomly allocated patients stratified by hospital and history of cirrhosis to receive plasma transfusion (10\u201315\u2009cc\/kg) or no transfusion. The primary outcome was change in hemoglobin concentration within 2\u2009days of procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 57 patients, mean age 56.0, 34 (59.6%) with cirrhosis, and mean INR 1.92 (SD\u00a0=\u00a00.27). In the intention to treat analysis, there were 10 of 27 (38.5%) participants in the plasma arm with a post procedure INR &lt;1.5 and one of 30 (3.6%) in the no treatment arm (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). The mean INR after receiving plasma transfusion was \u22120.24 (SD 0.26) lower than baseline. The change from pre\u2010procedure hemoglobin level to lowest level within 2\u2009days was \u22120.6 (SD\u00a0=\u00a01.0) in the plasma transfusion arm and \u22120.4 (SD\u00a0=\u00a00.6) in the no transfusion arm (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.29). Adverse outcomes were uncommon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We found no differences in change in hemoglobin concentration in those treated with plasma compared to no treatment. The change in INR was small and corrected to less than 1.5 in minority of patients. Large trials are required to establish if plasma is safe and efficacious.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16508","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T04:45:28Z","timestamp":1622522728000},"page":"2025-2034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>Plasma trial<\/scp>: Pilot randomized clinical trial to determine safety and efficacy of plasma transfusions"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-2833","authenticated-orcid":false,"given":"Jeffrey L.","family":"Carson","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Ness","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine, Department of Pathology Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5183-6471","authenticated-orcid":false,"given":"Monica B.","family":"Pagano","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire S.","family":"Philipp","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Arthur W.","family":"Bracey","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Mori","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Graduate School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Nosher","sequence":"additional","affiliation":[{"name":"Department of Radiology Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Hogshire","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helaine","family":"Noveck","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell J.","family":"Triulzi","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine, Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.00427.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02630.x"},{"issue":"2","key":"e_1_2_7_4_1","first-page":"S1","article-title":"Slowing decline in blood collection and transfusion in the United States \u2010 2017","volume":"60","author":"Jones JM","year":"2020","journal-title":"Transfusion"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.00422.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2016.01.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511271"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_7_10_1","unstructured":"National Healthcare Safety Network. CDC\/NHSN surveillance definitions for specific types of infections [monograph on the internet]. CDC; 2016.http:\/\/www.cdc.gov\/nhsn\/PDFs\/pscManual\/17pscNosInfDef_current.pdf"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12970"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1309\/NQXHUG7HND78LFFK"},{"key":"e_1_2_7_13_1","first-page":"1","volume-title":"Transfusion therapy: clinical principles and practice","author":"Callum JL","year":"2010"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2015.1.243"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00546.x"},{"key":"e_1_2_7_16_1","first-page":"324","article-title":"Predicting hemorrhage using preoperative coagulation screening assays","volume":"3","author":"Dzik WH","year":"2004","journal-title":"Curr Hematol Rep"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03691.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00184.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03690.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00891.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10129"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04868.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03247.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-370932"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04973.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03515.x"},{"key":"e_1_2_7_27_1","first-page":"213","article-title":"Correction of subclinical coagulation disorders before percutaneous dilatational tracheotomy","volume":"10","author":"Veelo DP","year":"2012","journal-title":"Blood Transfus"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12750"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02632.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2012.02.012"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2019.04.017"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2018.05.004"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-261891"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.74"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16508","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:42:36Z","timestamp":1693356156000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/trf.16508"],"URL":"https:\/\/doi.org\/10.1111\/trf.16508","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,31]]},"assertion":[{"value":"2021-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}