{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:06:00Z","timestamp":1790885160037,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In order to tackle the COVID\u201019 pandemic, a COVID\u201019 convalescent plasma (CCP) procurement program was initiated in Japan in April 2020. The program was a collaboration between a government\u2010managed national hospital, an infectious disease research institute, and a blood banking organization. Each party assumed different responsibilities: recruitment, SARS\u2010CoV\u20102 antibody profiling, and plasmapheresis; conduction of screening tests; and SARS\u2010CoV\u20102 blood testing, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We adopted a two\u2010point screening approach before the collected CCP was labeled as a CCP product for investigational use, for which we mainly tested anti\u2010SARS\u2010CoV\u20102 antibody eligibility and blood product eligibility. Anti\u2010SARS\u2010CoV\u20102 spike protein titer was measured using enzyme\u2010linked immunosorbent assay, and the IC<jats:sub>50<\/jats:sub> value was denoted as the neutralizing activity. Blood donor eligibility was extended beyond the normal blood donation guidelines to include a broader range of participants. After both eligibility criteria were confirmed, participants were asked to revisit the hospital for blood donation, which is a unique aspect of the Japanese CCP program, as most donations are taking place in normal blood donation venues in other countries. Some donors were re\u2010scheduled for repeat plasma donations. As public interest in anti\u2010SARS\u2010CoV\u20102 antibodies increased, test results were given to the participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As of September 17, 2020, our collection of CCP products was sufficient to treat more than 100 patients. As a result, projects for administration and distribution are also being conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We successfully implemented a CCP procurement scheme with the goal to expand to other parts of the country to improve treatment options for COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16541","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T01:38:04Z","timestamp":1623116284000},"page":"1998-2007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["How we secured a <scp>COVID<\/scp>\u201019 convalescent plasma procurement scheme in Japan"],"prefix":"10.1111","volume":"61","author":[{"given":"Mari","family":"Terada","sequence":"first","affiliation":[{"name":"Disease Control and Prevention Center National Center for Global Health and Medicine  Tokyo Japan"},{"name":"Center for Clinical Sciences National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6929-8955","authenticated-orcid":false,"given":"Satoshi","family":"Kutsuna","sequence":"additional","affiliation":[{"name":"Disease Control and Prevention Center National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomiteru","family":"Togano","sequence":"additional","affiliation":[{"name":"Emerging and Reemerging Infectious Diseases Graduate School of Medicine, Tohoku University  Sendai Japan"},{"name":"Department of Hematology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Saito","sequence":"additional","affiliation":[{"name":"Disease Control and Prevention Center National Center for Global Health and Medicine  Tokyo Japan"},{"name":"Emerging and Reemerging Infectious Diseases Graduate 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Accessed 10 Aug 2020."},{"issue":"2","key":"e_1_2_15_8_1","first-page":"152","article-title":"Convalescent plasma: new evidence for an old therapeutic tool?","volume":"14","author":"Marano G","year":"2016","journal-title":"Blood Transfus"},{"key":"e_1_2_15_9_1","unstructured":"World Health Organization Blood Regulators Network.Position paper on use of convalescent plasma serum or immune globulin concentrate as an element in response to emerging virus. 2017.https:\/\/www.who.int\/bloodproducts\/brn\/2017_BRN_PositionPaper_ConvalescentPlasma.pdf?ua=1. 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