{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:19:05Z","timestamp":1788347945302,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007877","name":"Fujita Health University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The occurrence of transfusion\u2010transmitted hepatitis B virus (HBV) infection has fallen dramatically due to continuous improvements in pre\u2010transfusion laboratory testing. However, the characteristics of transfusion\u2010transmitted HBV infection caused by individual donor nucleic acid amplification test (ID\u2010NAT)\u2010negative blood products are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 76\u2010year\u2010old woman with acute myeloid leukemia was diagnosed with transfusion\u2010transmitted HBV infection after receiving apheresis platelets derived from an ID\u2010NAT\u2010negative blood donation. This case was diagnosed definitively as transfusion\u2010mediated because complete nucleotide homology of a 1556\u2009bp region of the HBV Pol\/preS1\u2010preS2\u2010S genes and a 23\u2009bp region of the HBV core promoter\/precore between the donor and recipient strains was confirmed by PCR\u2010directed sequencing. The case is uncommon with respect to the unexpectedly prolonged HBV\u2010DNA incubation period of nearly 5\u00a0months after transfusion (previously, the longest period observed since the recent implementation of ID\u2010NAT pre\u2010transfusion laboratory testing in Japan was 84\u2009days). Slow\u2010replicating HBV genotype A2 may contribute to the prolonged incubation period; also, the quantity of apheresis platelets delivered in a large volume of plasma, and\/or the immune response of the recipient suffering from a hematological neoplasm, may have contributed to establishment of HBV infection in the recipient. This was supported by analysis of three previously documented cases of transfusion\u2010transmitted HBV infection by blood products derived from ID\u2010NAT\u2010negative donations in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Continuous monitoring of HBV infection for longer periods (&gt;3\u00a0months) may be required after transfusion of blood components from an ID\u2010NAT\u2010negative HBV window donation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16557","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T08:48:51Z","timestamp":1626252531000},"page":"2782-2787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prolonged incubation period of hepatitis B in a recipient of a nucleic acid amplification test\u2010negative hepatitis B virus window donation"],"prefix":"10.1111","volume":"61","author":[{"given":"Takahiro","family":"Matsuno","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion Fujita Health University Hospital  Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-3379","authenticated-orcid":false,"given":"Hideaki","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Fujita Health University Hospital  Toyoake Aichi Japan"},{"name":"Department of Molecular Laboratory Medicine Fujita Health University School of Medical Sciences  Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumie","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Cell Therapy Fujita Health University School of Medicine  Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Central Blood Institute, Blood Service Headquarters Japanese Red Cross Society  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-6839","authenticated-orcid":false,"given":"Masahiro","family":"Satake","sequence":"additional","affiliation":[{"name":"Central Blood Institute, Blood Service Headquarters Japanese Red Cross Society  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Aichi Blood Center  Seto Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Hematology Fujita Health University School of Medicine  Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Matsui","sequence":"additional","affiliation":[{"name":"School of Public Health, Division of Infectious Diseases and Vaccinology University of California, Berkeley  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukari","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Fujita Health University Hospital  Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9654-1300","authenticated-orcid":false,"given":"Yasuo","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Fujita Health University Hospital  Toyoake Aichi Japan"},{"name":"Department of Transfusion Medicine and Cell Therapy Fujita Health University School of Medicine  Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Japanese Red Cross Society.Transfusion information.2016.http:\/\/www.jrc.or.jp\/mr\/english\/pdf\/%E8%BC%B8%E8%A1%80%E6%83%85%E5%A0%B1_1707_154.pdf. Accessed 5 Jan 2021."},{"key":"e_1_2_7_3_1","unstructured":"Japanese Red Cross Society.Hemovigilance.2016.https:\/\/www.mhlw.go.jp\/file\/05\u2010Shingikai\u201011121000\u2010Iyakushokuhinkyoku\u2010Soumuka\/0000172575.pdf. Accessed 18 Dec 2020."},{"key":"e_1_2_7_4_1","unstructured":"Japanese Red Cross Society.Transfusion information.2017.http:\/\/www.jrc.or.jp\/mr\/english\/pdf\/TransfusionInformation_161.pdf. Accessed 5 Jan 2021."},{"key":"e_1_2_7_5_1","unstructured":"Japanese Red Cross Society.Hemovigilance.2017.https:\/\/www.mhlw.go.jp\/content\/11121000\/000336638.pdf. Accessed 18 Dec 2020."},{"key":"e_1_2_7_6_1","unstructured":"Japanese Red Cross Society.Transfusion information.2018.http:\/\/www.jrc.or.jp\/mr\/english\/pdf\/TransfusionInformation_167.pdf. Accessed 5 Jan 2021."},{"key":"e_1_2_7_7_1","unstructured":"Japanese Red Cross Society.Hemovigilance.2018.https:\/\/www.mhlw.go.jp\/content\/11127000\/000547090.pdf. Accessed 18 Dec 2020."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02156.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-833996"},{"key":"e_1_2_7_10_1","unstructured":"Japanese Red Cross Society.Blood services.2020.http:\/\/www.jrc.or.jp\/english\/pdf\/BloodServices2020.pdf. Accessed 4 Jan 2021."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(06)80005-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00029"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01723.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300832"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02081-08"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01522.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.048"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01276.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03909.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316490"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0359-5"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16557","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:55:42Z","timestamp":1693202142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,14]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/trf.16557"],"URL":"https:\/\/doi.org\/10.1111\/trf.16557","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,14]]},"assertion":[{"value":"2021-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}