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We aimed to determine the impact of the use of CCP transfusion in patients with previous circulating neutralizing antibodies (nAbs) in COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective cohort including 102 patients with COVID\u201019 transfused with ABO compatible CCP on days 0\u20132 after enrollment. Clinical status of patients was assessed using the adapted World Health Organization (WHO) ordinal scale on days 0, 5, and 14. The nAbs titration was performed using the cytopathic effect\u2010based virus neutralization test with SARS\u2010CoV\u20102 (GenBank MT126808.1). The primary outcome was clinical improvement on day 14, defined as a reduction of at least two points on the adapted WHO ordinal scale. Secondary outcomes were the number of intensive care unit (ICU)\u2010free days and the number of invasive mechanical ventilation\u2010free days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both nAbs of CCP units transfused (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) and nAbs of patients before CCP transfusions (<jats:italic>p<\/jats:italic>\u00a0=\u20090.028) were associated with clinical improvements by day 14. No significant associations between nAbs of patients or CCP units transfused were observed in the number of ICU or mechanical ventilation\u2010free days. Administration of CCP units after 10\u2009days of symptom onset resulted in a decrease in ICU\u2010free days (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) and mechanical ventilation\u2010free days (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transfusion of high titer nAbs CCP units may be a determinant in clinical strategies against COVID\u201019. We consider these data as useful parameters to guide future CCP transfusion practices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16573","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T07:02:50Z","timestamp":1624690970000},"page":"2295-2306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>COVID<\/scp>\u201019 convalescent plasma cohort study: Evaluation of the association between both donor and recipient neutralizing antibody titers and patient outcomes"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-8275","authenticated-orcid":false,"given":"Ana Paula H.","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-7733","authenticated-orcid":false,"given":"Silvano","family":"Wendel","sequence":"additional","affiliation":[{"name":"Hospital S\u00edrio\u2010Liban\u00eas Blood Bank  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5103-4970","authenticated-orcid":false,"given":"Carolina","family":"Bonet\u2010Bub","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta M.","family":"Fachini","sequence":"additional","affiliation":[{"name":"Hospital S\u00edrio\u2010Liban\u00eas Blood Bank  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula F.","family":"Dametto","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Blumm","sequence":"additional","affiliation":[{"name":"Hospital S\u00edrio\u2010Liban\u00eas  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-7432","authenticated-orcid":false,"given":"Valeria F.","family":"Dutra","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela T. 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