{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:49:56Z","timestamp":1790790596874,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T00:00:00Z","timestamp":1630195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate transfusion practices in pediatric oncology and hematopoietic stem cell transplant (HSCT) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design and methods<\/jats:title><jats:p>This is a multicenter retrospective study of children with oncologic diagnoses treated from 2013 to 2016 at hospitals participating in the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study\u2010III. Transfusion practices were evaluated by diagnosis codes and pre\u2010transfusion laboratory values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4766 inpatient encounters of oncology and HSCT patients were evaluated, with 39.3% (95% confidence interval [CI]: 37.9%\u201340.7%) involving a transfusion. Red blood cells (RBCs) were the most commonly transfused component (32.4%; 95% CI: 31.1%\u201333.8%), followed by platelets (22.7%; 95% CI: 21.5%\u201323.9%). Patients in the 1 to &lt;6\u2009years of range were most likely to be transfused and HSCT, acute myeloid leukemia, and aplastic anemia were the diagnoses most often associated with transfusion. The median hemoglobin (Hb) prior to RBC transfusion was 7.5\u00a0g\/dl (10\u201390th percentile: 6.4\u20138.8\u00a0g\/dl), with 45.7% of transfusions being given at 7 to &lt;8\u00a0g\/dl. The median platelet count prior to platelet transfusion was 20\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L (10\u201390th percentile: 8\u201351\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L), and 37.9% of transfusions were given at platelet count of &gt;20\u201350\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. The median international normalized ratio (INR) prior to plasma transfusion was 1.7 (10\u201390th percentile: 1.3\u20132.7), and 36.3% of plasma transfusions were given at an INR between 1.4 and 1.7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Transfusion of blood components is common in hospitalized pediatric oncology\/HSCT patients. Relatively high pre\u2010transfusion Hb and platelet values and relatively low INR values prior to transfusion across the studied diagnoses highlight the need for additional studies in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16626","type":"journal-article","created":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T19:38:30Z","timestamp":1630265910000},"page":"2589-2600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the <scp>National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study\u2010III (REDS\u2010III)<\/scp>"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-9905","authenticated-orcid":false,"given":"Ruchika","family":"Goel","sequence":"first","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Departments of Internal Medicine and Pediatrics, Division of Hematology Oncology Simmons Cancer Institute at SIU School of Medicine and ImpactLife (Mississippi Valley Regional Blood Center)  Springfield Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2697-6314","authenticated-orcid":false,"given":"Marianne E.","family":"Nellis","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Department of Pediatrics Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Karam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Children's Hospital of Richmond at VCU  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila J.","family":"Hanson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Medical College of Wisconsin and Children's Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-2245","authenticated-orcid":false,"given":"Christopher A.","family":"Tormey","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-5550","authenticated-orcid":false,"given":"Ravi M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Birch","sequence":"additional","affiliation":[{"name":"Public Health and Epidemiology Practice Westat  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce S.","family":"Sachais","sequence":"additional","affiliation":[{"name":"New York Blood Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha C.","family":"Sola\u2010Visner","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics Boston Children's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University  New Haven Connecticut USA"},{"name":"Department of Pathology &amp; Laboratory Medicine Service Veterans Affairs, Connecticut Healthcare System  West Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi L. 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