{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:34:33Z","timestamp":1783154073522,"version":"3.54.6"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Large clinical trials have demonstrated the overall safety of vaccines for severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102). However, reports have emerged of autoimmune phenomena, including vaccine\u2010associated myocarditis, immune thrombocytopenia, and immune thrombotic thrombocytopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>Here we present a novel case of a young woman who developed life\u2010threatening autoimmune hemolytic anemia (AIHA) after her first dose of a SARS\u2010CoV\u20102 mRNA vaccine. Notably, initial direct antiglobulin testing was negative using standard anti\u2010IgG reagents, which are \u201cblind\u201d to certain immunoglobulin (IgG) isotypes. Further testing using an antiglobulin reagent that detects all IgG isotypes was strongly positive and confirmed the diagnosis of AIHA. The patient required transfusion with 13 units of red blood cells, as well as treatment with corticosteroids, rituximab, mycophenolate mofetil, and immune globulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As efforts to administer SARS\u2010CoV\u20102 vaccines continue globally, clinicians must be aware of potential autoimmune sequelae of these therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16672","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T09:40:10Z","timestamp":1632303610000},"page":"3267-3271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Severe autoimmune hemolytic anemia following receipt of <scp>SARS\u2010CoV<\/scp>\u20102 <scp>mRNA<\/scp> vaccine"],"prefix":"10.1111","volume":"61","author":[{"given":"Sanjay R. V.","family":"Gadi","sequence":"first","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A. R.","family":"Brunker","sequence":"additional","affiliation":[{"name":"Blood Transfusion Service, Department of Pathology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-1383","authenticated-orcid":false,"given":"Hanny","family":"Al\u2010Samkari","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Sykes","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Center for Regenerative Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-0985","authenticated-orcid":false,"given":"Rebecca R.","family":"Saff","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Bendapudi","sequence":"additional","affiliation":[{"name":"Blood Transfusion Service, Department of Pathology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Division of Hematology and Oncology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Division of Hemostasis and Thrombosis Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Leaf","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9978-8779","authenticated-orcid":false,"given":"Rebecca Karp","family":"Leaf","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003808"},{"key":"e_1_2_7_3_1","unstructured":"Advisory Committee on Immunization Practices (ACIP)COVID\u201019 VaST Work Group Technical Report \u2013 May 17 2021. 2021."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26132"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104882"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104840"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13812"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-583021"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40080907.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.151"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.11.014"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16672","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16672","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:02:48Z","timestamp":1693191768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,3]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/trf.16672"],"URL":"https:\/\/doi.org\/10.1111\/trf.16672","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,3]]},"assertion":[{"value":"2021-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}