{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:26:27Z","timestamp":1792070787438,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blood donation is associated with a loss of hemoglobin (Hb)\u2010bound iron. Hb levels recover relatively fast by using stored iron. However, it takes more time to replenish iron stores, potentially resulting in iron deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Hb and ferritin levels were measured in 5056 new, first\u2010time, and repeat whole blood donors. We investigated whether increasing numbers of donations are associated with lower ferritin levels. Furthermore, we tested whether low ferritin levels are associated with low\u2010Hb deferral at the subsequent donation attempt by performing logistic regression adjusted for age and stratified by sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Whereas mean Hb levels are relatively stable, ferritin levels significantly decrease with increasing numbers of donations and were approximately 50% lower for donors with &gt;50 donations compared with those with 2\u201310 donations. Despite the poor correlation of ferritin and Hb levels, cross\u2010sectional, iron\u2010deficient donors (ferritin &lt;15\u2009ng\/ml) had 21.8 (8.5\u201355.6) higher odds in men, 10.1 (6.1\u201316.5) in premenopausal women, and 11.7 (5.2\u201326.4) in postmenopausal women for Hb deferral at a subsequent visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>To conclude, repeated donations may induce iron deficiency, which corresponds with an over tenfold increased risk of having insufficiently restored Hb levels at a subsequent donation attempt. Longer donation intervals and\/or higher dietary or supplemental iron intake are warranted to prevent accumulated iron depletion and subsequent low\u2010Hb deferral in whole blood donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16688","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T01:30:58Z","timestamp":1633138258000},"page":"3344-3352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Donation\u2010induced iron depletion is significantly associated with low hemoglobin at subsequent donations"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7849-0092","authenticated-orcid":false,"given":"Femmeke J","family":"Prinsze","sequence":"first","affiliation":[{"name":"Department of Donor Medicine Research, Donor Studies Sanquin Research  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Research, Donor Studies Sanquin Research  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany C.","family":"Timmer","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Research, Donor Studies Sanquin Research  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1950-831X","authenticated-orcid":false,"given":"Saurabh","family":"Zalpuri","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Research, Donor Studies Sanquin Research  Amsterdam the Netherlands"},{"name":"UCB Pharma, Real World Evidence  Breda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"van den Hurk","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Research, Donor Studies Sanquin Research  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"39","volume-title":"Blood donor selection: Guidelines on assessing donor suitability for blood donation: Chapter 4","author":"World Health Organization","year":"2012"},{"key":"e_1_2_7_3_1","volume-title":"Guide to the preparation, use and quality assurance of blood components","author":"European Committee (Partial Agreement) on Blood Transfusion (CD\u2010P\u2010TS )","year":"2017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2007.00818.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15676"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12431"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12527"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13152"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15906"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-04648-w"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2019.10.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500679"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15303"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13195"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.09.009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13691"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31928-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-04-709451"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-6892.2004.00448.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/42.5.718"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.4.800"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12207"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02989.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01903.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02881.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2007.00962.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14998"},{"issue":"4","key":"e_1_2_7_28_1","first-page":"274","article-title":"Donor iron deficiency study (DIDS): protocol of a study to test whether iron deficiency in blood donors affects red blood cell recovery after transfusion","volume":"17","author":"Bitan ZC","year":"2019","journal-title":"Blood Transfus"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499768"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13011"},{"key":"e_1_2_7_31_1","unstructured":"Jaarverslag Sanquin 2018. (Yearly report)."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12809"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12731"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13066"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03401.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02865.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509026"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/62.3.611"},{"issue":"10","key":"e_1_2_7_39_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186662","article-title":"Associations of health status with subsequent blood donor behavior\u2014an alternative perspective on the healthy donor effect from donor InSight","volume":"12","author":"Hurk K","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12750"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15509"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.119"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12380"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08952.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051313"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25800"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12856"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2019.07.005"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.03.025"},{"key":"e_1_2_7_50_1","article-title":"Oral or parenteral iron supplementation to reduce deferral, iron deficiency and\/or anaemia in blood donors","volume":"7","author":"Smith GA","year":"2014","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16688","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T03:28:17Z","timestamp":1714620497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/trf.16688"],"URL":"https:\/\/doi.org\/10.1111\/trf.16688","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2021-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}