{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:15:11Z","timestamp":1788992111782,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In 2020, of 110,000 blood donors screened for HIV exposure two individuals were identified who were viral RNA\u2010positive but seronegative. One of the donors, borderline negative in a pooled screening test for HIV RNA, utilized antiretroviral drugs as post\u2010exposure, pre\u2010donation prophylaxis. The kinetics of subsequent HIV seropositivity in both donors are described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Both donors were recalled and interviewed, and blood was obtained at intervals for HIV antibodies and RNA testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One donor used antiretroviral prophylaxis for 30\u2009days due to a relationship with an HIV\u2010positive partner. In follow\u2010up samples, seroconversion was noted at 70\u2009days, and viral RNA was detected at 105\u2009days, after blood donation. In contrast, the other donor seroconverted in &lt;25\u2009days and the appearance and titer of HIV RNA was in accordance with the typical pre\u2010seroconversion window.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of anti\u2010viral prophylaxis by blood donors in the acute phase of HIV infection delays seroconversion. A 6\u2010month deferral in blood donation after HIV prophylaxis, as currently recommended in Brazil, would have been sufficient in this case to mitigate the risk of transfusion\u2010transmitted HIV. Ultimately, improvement in donor compliance with selection procedures for blood donation is needed to optimize blood safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16698","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T13:07:20Z","timestamp":1633784840000},"page":"3488-3492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Influence of unreported <scp>HIV<\/scp> prophylaxis on the kinetics of post\u2010blood donation <scp>HIV<\/scp> seroconversion"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-1999","authenticated-orcid":false,"given":"Anna S.","family":"Nishiya","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Laboratory of Medical Investigation in Pathogenesis and targeted therapy in Oncoimmunohematology (LIM\u201031), Department of Hematology Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanci A.","family":"Salles","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-4634","authenticated-orcid":false,"given":"Cesar","family":"de Almeida\u2010Neto","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Disciplina de Ci\u00eancias M\u00e9dicas Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3502-3929","authenticated-orcid":false,"given":"Steven S.","family":"Witkin","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Obstetrics and Gynecology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4190-0238","authenticated-orcid":false,"given":"Suzete C.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Laboratory of Medical Investigation in Pathogenesis and targeted therapy in Oncoimmunohematology (LIM\u201031), Department of Hematology Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima A. 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