{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:33:10Z","timestamp":1753885990228,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low\u2010titer group O whole blood (LTOWB) is attractive for acute trauma care as it delivers concentrated and balanced hemostatic resuscitation in single large bags. Whether cold\u2010stored LTOWB can sustain platelet counts is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Four cohorts of trauma patients\u2014three historic, one retrospective\u2014were identified by their urgency of blood use. Admission and all subsequent platelet counts over the first 24\u2009h of care were compared with <jats:italic>t<\/jats:italic>\u2010tests. The cohorts were as follows: 1292 patients at Maryland Shock Trauma as described by Stansbury and colleagues in 2013; 35 patients enrolled locally in the 1:1:2 arm of the pragmatic randomized optimal plasma and platelet ratios (PROPPR) trial; 34 patients enrolled locally in the 1:1:1 arm of PROPPR; and 59 patients receiving more than 3\u00a0units of LTOWB enroute to or at our Level 1 trauma center, 2019\u20132020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age of LTOWB units transfused was 9\u00a0\u00b1\u20095\u2009days and mean dose was 5\u00a0\u00b1\u20092\u00a0units. All four cohorts were profoundly injured (mean Injury Severity Score\u2009\u2265\u200931), with mean first platelet counts 204\u2013228\u2009K\/\u03bc and subsequent counts approximately 100\u2009k\/\u03bcl lower. Through the first 24\u2009h of care, mean platelet counts decreased least, 79 and 83 10<jats:sup>3<\/jats:sup>\/\u03bcl, in the 1:1:1 PROPPR and LTOWB cohorts. Mean platelet counts in patients transfused with LTOWB remained stable after the third hour of care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>LTOWB transfusion was associated with lesser mean decrease in platelet counts during the first 24\u2009h after injury, similar to those observed among patients receiving components 1:1:1 component in the PROPPR study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16699","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T15:08:39Z","timestamp":1634224119000},"page":"3321-3327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cold\u2010stored whole blood and platelet counts in severe acute injury: A comparison of four retrospective 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