{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:30:46Z","timestamp":1769923846590,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The balance between ensuring blood donor and recipient safety while maintaining a sufficient blood supply can be affected by excessive deferral of blood donors. In 2018, a biannual regulatory review of donor eligibility criteria provided the South African National Blood Service (SANBS) the opportunity to review the existing criteria. Changes to these criteria were implemented in April 2019 after an extensive review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study of SANBS whole\u2010blood donor presentations to determine the impact of the changed donor eligibility criteria on deferrals and blood safety. We compared donor presentations, deferrals, and HIV\u2010positive cases for the 12\u2010month period (April 2019\u2013March 2020) after the implementation of the updated donor eligibility criteria to those of the previous year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 2,112,917 donor presentations, 51.1% (1079506) occurred in the post\u2010implementation study period. Overall, deferrals decreased from 18.6% to 14.5%, whereas HIV\u2010positive donations increased by 0.03%. A multivariable logistic regression analysis adjusted for sex, age, geographical location, donor, and clinic type showed significantly lower odds of deferral (OR 0.70; 95% CI: 0.69\u20130.70) and greater odds of HIV\u2010positive cases in the study period than those in the control period (OR 1.17; 95% CI: 1.10\u20131.25).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We confirmed that the change in donor eligibility criteria was associated with a decrease in deferrals and an increase in the country's blood supply. The impact of the increased number of HIV\u2010positive donations on blood safety in a country performing individual donation nucleic acid amplification testing requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16702","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T02:07:53Z","timestamp":1634436473000},"page":"3361-3371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Re\u2010engineering the medical assessment of blood donors in South Africa: The balance between supply and safety"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8669-3423","authenticated-orcid":false,"given":"Thabiso","family":"Rapodile","sequence":"first","affiliation":[{"name":"Medical department, Collections department, IT department South African National Blood Service (SANBS)  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Mitchel","sequence":"additional","affiliation":[{"name":"Medical department, Collections department, IT department South African National Blood Service (SANBS)  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronel","family":"Swanevelder","sequence":"additional","affiliation":[{"name":"Medical department, Collections department, IT department South African National Blood Service (SANBS)  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward L.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine and Epidemiology\/Biostatistics University of California San Francisco  San Francisco California USA"},{"name":"Affiliate Investigator Vitalant Research Institute  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Medical department, Collections department, IT department South African National Blood Service (SANBS)  Johannesburg South Africa"},{"name":"Translational Research Department, Medical Division South African National Blood Service  Roodepoort South Africa"},{"name":"Division of Clinical Haematology, Department of Medicine, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"},{"name":"Division of Clinical Haematology University of the Free State  Bloemfontein South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"SA S.Mid\u2010year population estimates 2019;2019.http:\/\/www.statssa.gov.za\/publications\/P0302\/P03022020.pdf"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12939-019-1055-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.5.557"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2012.04.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15288"},{"key":"e_1_2_6_7_1","unstructured":"2012 WHO.WHO Guidelines Approved by the Guidelines Review Committee. Blood donor selection: guidelines on assessing donor suitability for blood donation. Geneva: World Health Organization; 2012.2012."},{"key":"e_1_2_6_8_1","unstructured":"SANBS.South African National Blood services (SANBS) Annual Integrated Report;2020.https:\/\/sanbs.org.za\/wp-content\/uploads\/2021\/02\/Annual-Report-21-December-2020.pdf"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6918.1517"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12179"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12056"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2017.07.005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04160.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-019-4352-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180-2013-7110002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.5.519"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1970479"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02037.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15421"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206487"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2007.00897.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.06.020"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12046"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.187938"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12622"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12951"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02793.x"},{"issue":"3","key":"e_1_2_6_28_1","first-page":"441","article-title":"Changing blood donor screening criteria from permanent deferral for men who have sex with men to individual sexual risk assessment: no evidence of a significant impact on the human immunodeficiency virus epidemic in Italy","volume":"11","author":"Suligoi B","year":"2013","journal-title":"Blood Transfus"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.18-4-304"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12867"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14959"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16702","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T03:28:42Z","timestamp":1714620522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,13]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/trf.16702"],"URL":"https:\/\/doi.org\/10.1111\/trf.16702","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,13]]},"assertion":[{"value":"2021-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}