{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:03:43Z","timestamp":1770915823619,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR003142"],"award-info":[{"award-number":["UL1TR003142"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The reported incidence of adverse reactions following Coronavirus disease 2019 (COVID\u201019) convalescent plasma (CCP) transfusion has generally been lower than expected based on the incidence of transfusion reactions that have been observed in studies of conventional plasma transfusion. This raises the concern for under\u2010reporting of adverse events in studies of CCP that rely on passive surveillance strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Our institution implemented a protocol to actively identify possible adverse reactions to CCP transfusion. In addition, we retrospectively reviewed the charts of inpatients who received CCP at Stanford Hospital between May 13, 2020 and January 31, 2021. We determined the incidence of adverse events following CCP transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 49 patients received CCP. Seven patients (14%) had an increased supplemental oxygen requirement within 4\u2009h of transfusion completion, including one patient who was intubated during the transfusion. An additional 11 patients (total of 18, 37%) had increased oxygen requirements within 24\u2009h of transfusion, including 3 patients who were intubated. Six patients (12%) fulfilled criteria for transfusion\u2010associated circulatory overload (TACO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using an active surveillance strategy, we commonly observed adverse events following the transfusion of CCP to hospitalized patients. It was not possible to definitively determine whether or not these adverse events are related to CCP transfusion. TACO was likely over\u2010diagnosed given overlap with the manifestations of COVID\u201019. Nevertheless, these results suggest that the potential adverse effects of CCP transfusion may be underestimated by reports from passive surveillance studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16711","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T13:58:57Z","timestamp":1634911137000},"page":"28-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Active surveillance of serious adverse events following transfusion of <scp>COVID<\/scp>\u201019 convalescent plasma"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7195-9644","authenticated-orcid":false,"given":"Erica","family":"Swenson","sequence":"first","affiliation":[{"name":"Department of Pathology Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9051-2090","authenticated-orcid":false,"given":"Lisa Kanata","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perrin","family":"Jhaveri","sequence":"additional","affiliation":[{"name":"Department of Hematology Kaiser Permanente  Renton Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Medicine, Quantitative Sciences Unit Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanthi","family":"Kappagoda","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases and Geographic Medicine Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3614-2353","authenticated-orcid":false,"given":"Suchitra","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford California USA"},{"name":"Stanford Blood Center  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-2955","authenticated-orcid":false,"given":"Angelica","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Ruoss","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aruna","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases and Geographic Medicine Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2237-6645","authenticated-orcid":false,"given":"Marie","family":"Hollenhorst","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford California USA"},{"name":"Department of Medicine, Division of Hematology Stanford University  Stanford California USA"},{"name":"Chemistry, Engineering, &amp; Medicine for Human Health Institute (ChEM\u2010H) Stanford University  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.06.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.04.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14245"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03663.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12994"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03247.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12234"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13212"},{"key":"e_1_2_8_10_1","unstructured":"EUA Fact Sheet for Health Care Providers COVID\u201019 Convalescent Plasma. FDA February 4 2021."},{"key":"e_1_2_8_11_1","unstructured":"Convalescent Plasma COVID\u201019 Emergency Use Authorization. (2021). Retrieved March 8 2021 fromhttps:\/\/www.uscovidplasma.org\/"},{"key":"e_1_2_8_12_1","first-page":"20169359","article-title":"Effect of convalescent plasma on mortality among hospitalized patients with COVID\u201019: initial three\u2010month experience","author":"Joyner MJ","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.06.028"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI140200"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2031893"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16177"},{"key":"e_1_2_8_17_1","volume-title":"Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases","author":"U.S. Centers for Disease Control and Prevention","year":"2018"},{"key":"e_1_2_8_18_1","unstructured":"NakazawaM(2019).Fmsb: functions for medical statistics book with some demographic data. 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