{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:02:57Z","timestamp":1783728177119,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bombay phenotype (O<jats:sub>h<\/jats:sub>) is a rare blood group and poses unique challenges during pregnancy, including an adequate supply of blood products in case of postpartum hemorrhage (PPH) and the risk of hemolytic disease of the fetus and newborn (HDFN). Case reports of antenatal care in this cohort are scarce. Herein, we present a case of twin pregnancy in an O<jats:sub>h<\/jats:sub> woman and outline her multidisciplinary management. We summarize the literature to better inform decision\u2010making and patient blood management in the antenatal care of O<jats:sub>h<\/jats:sub> women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case description<\/jats:title><jats:p>A 22\u2010year\u2010old G1P0 presented at 15\u2009weeks gestation with dichorionic diamniotic twins and known O<jats:sub>h<\/jats:sub> phenotype. Hematinics were optimized to minimize anemia. Anti\u2010H titers were tracked and were 1:256 at both 28 and 36\u2009weeks gestation. Regular middle cerebral artery dopplers were performed to assess for fetal anemia. There was constant communication with obstetrics and anesthetics teams. Both autologous frozen and directly donated fresh red cells were available as part of a clear, detailed transfusion plan. Transfusion was not required and neither child was affected by HDFN. The neonates were group O, DAT negative, and group A, DAT positive. Maternal anti\u2010A was detected in the neonatal eluate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this is only the second report of twin pregnancy in an O<jats:sub>h<\/jats:sub> female and the first time a detailed transfusion plan has been published. Through employing patient blood management strategies, engaging a collaborative multidisciplinary approach, and establishing a clear delivery plan, the antenatal challenges of Bombay phenotype are surmountable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16737","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T13:24:25Z","timestamp":1637155465000},"page":"247-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Navigating the challenges of Bombay phenotype (O<sub>h<\/sub>) and twin pregnancy; a case report and literature review"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6964-9591","authenticated-orcid":false,"given":"Michael","family":"Krigstein","sequence":"first","affiliation":[{"name":"Department of Hematology Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8368-2374","authenticated-orcid":false,"given":"Natalie","family":"Cromer","sequence":"additional","affiliation":[{"name":"Department of Hematology Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"105","article-title":"Molecular genetics of H","volume":"78","author":"Oriol R","year":"2000","journal-title":"Vox Sang"},{"issue":"6714","key":"e_1_2_7_3_1","first-page":"903","article-title":"A \"new\" blood group character related to the ABO system","volume":"1","author":"Bhende YM","year":"1952","journal-title":"Lancet"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-397164-7.00023-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.9.4632"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-056"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1978.18679077959.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14906"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2002.00407.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610500150585"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2012.06.026"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/GJTM.GJTM_12_17"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.341195065027.x"},{"key":"e_1_2_7_14_1","first-page":"8850500","article-title":"Elderly gravida with Bombay blood group and placenta previa managed with autologous blood transfusion","volume":"2020","author":"Paudyal P","year":"2020","journal-title":"Case Rep Obstet Gynecol"},{"issue":"7","key":"e_1_2_7_15_1","first-page":"1376","article-title":"Bombay blood group and pregnancy","volume":"49","author":"Qian J","year":"2020","journal-title":"Iran J Public Health"},{"issue":"8","key":"e_1_2_7_16_1","first-page":"e9758","article-title":"Secondary postpartum hemorrhage presenting with Bombay blood group: a case report","volume":"12","author":"Shaik L","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.115583"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181f738f3"},{"key":"e_1_2_7_19_1","volume-title":"Patient blood management guidelines: module 5 \u2013 obstetrics and maternity","author":"National Blood Authority (NBA)","year":"2015"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12420"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM_737_19"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1980.tb04455.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200006000-00022"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.07.007"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1583736"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2019.1629400"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16737","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:22:27Z","timestamp":1693210947000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,17]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/trf.16737"],"URL":"https:\/\/doi.org\/10.1111\/trf.16737","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,17]]},"assertion":[{"value":"2021-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}