{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:06:55Z","timestamp":1747188415635,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In addition to antigen\u2010negative red blood cells (RBC), Immunohematology Reference Laboratories (IRL) must provide RBCs that are cytomegalovirus (CMV) seronegative. Due to high percentage of CMV seropositive individuals, it is challenging to find CMV and antigen\u2010negative RBC. The IRL selects predominantly group O donors tested for CMV, and these RBC are sometimes needed to fill orders for nongroup O patients. This study evaluated units sent that were out of group to fulfill CMV\u2010seronegative requests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Requests for CMV\u2010seronegative and antigen\u2010negative RBCs were divided into Period 1 (January 1, 2019\u2013February 29, 2020) before intervention and Period 2 (March 1, 2020\u2013May 31, 2020) post intervention. ABO Rh units requested were compared to ABO Rh units provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Period 1: 537 CMV\u2010seronegative RBC units were provided. 99\/188(52.66%) B\u2010positive requests were fulfilled using O RBCs. 58\/504 (11.51%) of D\u2010negative units were sent to D\u2010positive patients.<\/jats:p><jats:p>Period 2: 119 CMV\u2010seronegative RBC units were provided. 18\/51 (35.29%) B positive requests were fulfilled using O RBCs. Only 7\/113 (6.19%) D\u2010negative units were sent to D\u2010positive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>For 239\/656 (36.43%) CMV\u2010seronegative antigen orders requested for B\u2010positive patients, more than half of these orders were filled with O RBCs. To decrease group O usage for nongroup O patients, the IRL practice has changed to increase CMV testing for group B donors. Since the change in algorithm, there was a 17.37% decrease group O usage for group B patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16742","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T09:35:37Z","timestamp":1638869737000},"page":"151-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CMV<\/scp> screening of group\u2010specific orders\u2014good stewardship of the blood supply"],"prefix":"10.1111","volume":"62","author":[{"given":"Tara","family":"Francis","sequence":"first","affiliation":[{"name":"OneBlood, Immunohematology Reference Laboratory  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Delk","sequence":"additional","affiliation":[{"name":"OneBlood, Immunohematology Reference Laboratory  Fort Lauderdale Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1175-9579","authenticated-orcid":false,"given":"Richard R.","family":"Gammon","sequence":"additional","affiliation":[{"name":"OneBlood, Scientific, Medical, Technical Direction  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13503"},{"issue":"7","key":"e_1_2_7_3_1","first-page":"S701\u2013S710","article-title":"Epidemiology of cytomegalovirus infections","volume":"12","author":"Ho M","year":"1990","journal-title":"Rev Infect Dis"},{"key":"e_1_2_7_4_1","first-page":"297","volume-title":"Technical manual","author":"Olsson ML","year":"2020"},{"key":"e_1_2_7_5_1","unstructured":"Inc Rev 2013 9 Global antigen frequency chart immucor"},{"key":"e_1_2_7_6_1","first-page":"173","volume-title":"Technical manual","author":"Crowder LA","year":"2020"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/tmrv.2001.19946"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2005.02.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.9.3598.bloodjournal8693598"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14920"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.1360"},{"key":"e_1_2_7_12_1","first-page":"389","volume-title":"Technical manual","author":"Er L","year":"2020"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12146"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-490623"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1990.tb02055.x"},{"volume-title":"Applied blood group serology","year":"1998","author":"Issitt PD","key":"e_1_2_7_16_1"},{"key":"e_1_2_7_17_1","article-title":"Recommendations for the use of Group O red blood cells","author":"Murphy M","year":"2019","journal-title":"AABB Assoc Bull"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14168"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14547"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16742","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:21:17Z","timestamp":1693210877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/trf.16742"],"URL":"https:\/\/doi.org\/10.1111\/trf.16742","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2021,12,7]]},"assertion":[{"value":"2021-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}