{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T20:25:09Z","timestamp":1769977509710,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have described associations between ABO blood group and SARS\u2010CoV\u20102 infection severity in hospitalized patients where group A individuals are over\u2010represented and group O individuals may have a lower infection rate. In convalescent individuals, group B blood donors have higher neutralizing SARS\u2010CoV\u20102 antibody titers. We analyzed whether there was any correlation of ABO Rh(D) blood group with SARS\u2010CoV\u20102 infection and with neutralizing antibodies in Australian convalescent plasma (CP) donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>ABO Rh(D) distribution and demographics of CP donors (<jats:italic>n<\/jats:italic>\u00a0=\u00a0765) were compared with the total blood donor panel (<jats:italic>n<\/jats:italic>\u00a0=\u00a0488,028), plasmapheresis donors (<jats:italic>n<\/jats:italic>\u00a0=\u00a0203,176) and whole blood donors (<jats:italic>n<\/jats:italic>\u00a0=\u00a0282,437) from 2020. The presence of neutralizing antibodies in CP donors was measured using the Vero E6 cell microneutralization assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of ABO group in CP donors compared to the total donor panel was not significantly different (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.177). There were significantly more group AB donors in the plasmapheresis subset (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.005) and group O individuals were over\u2010represented in the whole blood donor subset (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). There was no significant difference in neutralizing antibody levels among CP donors with differing ABO blood groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.872).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ABO Rh(D) blood group distribution was not found to be significantly different between convalescent plasma donors and general blood donors in our large sample group. Inherent blood donor selection biases associated with clinical demand accounted for some differences within CP donors. The levels of SARS\u2010CoV\u20102 neutralizing antibodies were also not significantly associated with ABO Rh(D) group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16781","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T13:31:39Z","timestamp":1640179899000},"page":"292-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Absence of correlation between <scp>ABO<\/scp> Rh(D) blood group and neutralizing antibody titers in <scp>SARS\u2010CoV<\/scp>\u20102 convalescent plasma donors"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0371-9515","authenticated-orcid":false,"given":"Rena","family":"Hirani","sequence":"first","affiliation":[{"name":"Clinical Services and Research Australian Red Cross Lifeblood  Australia"},{"name":"Department of Molecular Sciences, Faculty of Science and Engineering Macquarie University  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7827-3661","authenticated-orcid":false,"given":"Veronica","family":"Hoad","sequence":"additional","affiliation":[{"name":"Clinical Services and Research Australian Red Cross Lifeblood  Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain B.","family":"Gosbell","sequence":"additional","affiliation":[{"name":"Clinical Services and Research Australian Red Cross Lifeblood  Australia"},{"name":"School of Medicine Western Sydney University  Penrith Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David O.","family":"Irving","sequence":"additional","affiliation":[{"name":"Clinical Services and Research Australian Red Cross Lifeblood  Australia"},{"name":"Faculty of Nursing, Midwifery &amp; Health University of Technology Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization (WHO) Coronavirus (COVID\u201019) dashboard.2021. Available from:https:\/\/covid19.who.int\/. Accessed 8 October 2021."},{"key":"e_1_2_7_3_1","unstructured":"Australian Government Department of Health.COVID\u201019 Australia: Epidemiology Report 42. 2021. Available from:https:\/\/www1.health.gov.au\/internet\/main\/publishing.nsf\/Content\/C50CAE02452A48A7CA2587320081F7BF\/$File\/covid_19_australia_epidemiology_report_42_reporting_period_ending_23_may_2021.pdf. Accessed 8 October 2021."},{"key":"e_1_2_7_4_1","unstructured":"Australian Bureau of Statistics.National state and territory population.2021.https:\/\/www.abs.gov.au\/statistics\/people\/population\/national-state-and-territory-population\/mar-2021. Accessed 8 October 2021."},{"key":"e_1_2_7_5_1","unstructured":"Australian Government Department of Health. Coronavirus (COVID\u201019) case numbers and statistics.2021. Available from:https:\/\/www.health.gov.au\/news\/health\u2010alerts\/novel\u2010coronavirus\u20102019\u2010ncov\u2010health\u2010alert\/coronavirus\u2010covid\u201019\u2010current\u2010situation\u2010and\u2010case\u2010numbers. 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