{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T09:33:54Z","timestamp":1782725634808,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Resistance to malaria infection may be conferred by erythrocyte genetic variations including glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency and lack of Duffy antigens. In red blood cell (RBC) transfusion, G6PD deficiency may shorten transfusion survival. Because Duffy\u2010null units are commonly transfused in sickle cell disease (SCD) due to antigen matching protocols, we examined whether Duffy\u2010null donor RBC units have a higher prevalence of G6PD deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Pediatric patients with SCD on chronic transfusion therapy were followed prospectively for multiple transfusions. RBC unit segments were collected to measure G6PD activity and RBC genotyping. The decline in donor hemoglobin (\u0394HbA) following transfusion was assessed from immediate posttransfusion estimates and HbA measurements approximately 1\u00a0month later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 564 evaluable RBC units, 59 (10.5%) were G6PD deficient (23 severe, 36 moderate deficiency); 202 (37.6%) units were Duffy\u2010null. G6PD deficiency occurred in 40 (19.8%) Duffy\u2010null units versus 15 (4.5%) Duffy\u2010positive units (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). In univariate analysis, the fraction of Duffy\u2010null RBC units per transfusion was associated with greater decline in HbA (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.038); however, in multivariate analysis, severe G6PD deficiency (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0238) but not Duffy\u2010null RBC (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0139) were associated with \u0394HbA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Selection of Duffy\u2010null RBC units may result in shorter in vivo survival of transfused RBCs due to a higher likelihood of transfusing units from G6PD deficient donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16806","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T14:12:57Z","timestamp":1642601577000},"page":"551-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Glucose\u20106\u2010phosphate dehydrogenase deficiency is more prevalent in Duffy\u2010null red blood cell transfusion in sickle cell disease"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6082-8385","authenticated-orcid":false,"given":"Marianne E.","family":"Yee","sequence":"first","affiliation":[{"name":"Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta  Atlanta Georgia USA"},{"name":"Department of Pediatrics, Division of Hematology\/Oncology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard O.","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center, New York Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi L. C.","family":"Luban","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders, Children's National Medical Center, Departments of Hematology and Laboratory Medicine George Washington University School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk A.","family":"Easley","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Rollins School of Public Health  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Lough","sequence":"additional","affiliation":[{"name":"Lifesouth Community Blood Centers  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Roback","sequence":"additional","affiliation":[{"name":"Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-991X","authenticated-orcid":false,"given":"Cassandra D.","family":"Josephson","sequence":"additional","affiliation":[{"name":"Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta  Atlanta Georgia USA"},{"name":"Department of Pediatrics, Division of Hematology\/Oncology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8692-4041","authenticated-orcid":false,"given":"Ross M.","family":"Fasano","sequence":"additional","affiliation":[{"name":"Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2008.12.005"},{"issue":"6","key":"e_1_2_9_3_1","first-page":"601","article-title":"Glucose\u20106\u2010phosphate dehydrogenase deficiency. 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