{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:18:42Z","timestamp":1780067922793,"version":"3.54.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Glycosylated hemoglobin (HbA1c), not routinely screened in blood donors, is associated with morphological, biochemical, and functional abnormalities of red blood cells (RBCs) and with enhanced oxidative stress. We aimed to explore HbA1c levels in blood donors and their effect on RBC storage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>An analytical cross\u2010sectional study was conducted on 875 eligible blood donors aged 18\u201360\u2009years from May 1, 2021, to August 30, 2021. Two selected groups of donors (HbA1c &lt;6.5%, <jats:italic>n<\/jats:italic>\u00a0=\u00a010; HbA1c \u2265\u20096.5%, <jats:italic>n<\/jats:italic>\u00a0=\u00a010) exhibiting as similar as possible baseline values (such as age, sex, and living habits, etc.) were recruited for blood donation in leukoreduced CPDA\u20101\u00a0units. RBC morphological, biochemical, structural, and oxidative stress states were measured during 5\u201335\u2009days of storage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Elevated HbA1c prevalence was 37%, including 31.7% (277\/875) in the prediabetes range (HbA1c 5.7%\u20136.4%) and 5.4% (47\/875) in the diabetes range (HbA1c \u2265\u20096.5%). Age, body mass index (BMI), smoking, and alcohol consumption were the main factors influencing the HbA1c levels. During storage, high\u2010HbA1c group had abnormal RBC morphology, impaired membrane function, and ion imbalance (higher mean corpuscular volume, distribution width, hemolysis rate, potassium ion efflux, and phosphatidylserine exposure) as compared with low HbA1c group. Additionally, RBC oxidative stress was significantly increased in donors with high HbA1c levels during 21\u201335\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Blood donors proportion with abnormal HbA1c levels was relatively high, and donor HbA1c levels may be associated with stored RBCs capacity. Our study provides new insights into the different effects of donor HbA1c levels on RBC storage lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16815","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T12:59:59Z","timestamp":1644411599000},"page":"663-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The relationship between glycosylated hemoglobin level and red blood cell storage lesion in blood donors"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5888-2147","authenticated-orcid":false,"given":"Hongyan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion Xiangya Second Hospital, Central South University  Changsha Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuiming","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Blood Quality Management Yueyang Central Blood Bank  Yueyang City Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Blood Quality Management Yueyang Central Blood Bank  Yueyang City Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"He","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Xiangya Second Hospital, Central South University  Changsha Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Xiangya Second Hospital, Central South University  Changsha Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00914"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13460"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.03.012"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"27","article-title":"Red blood cell storage lesion: causes and potential clinical consequences","volume":"17","author":"Yoshida T","year":"2019","journal-title":"Blood Transfus"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2020.102876"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16017"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15811"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15812"},{"issue":"3","key":"e_1_2_8_10_1","first-page":"224","article-title":"Sex\u2010related aspects of the red blood cell storage lesion","volume":"19","author":"Tzounakas VL","year":"2021","journal-title":"Blood Transfus"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061337"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.246603"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.273946"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00248"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02920.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2016.11.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(68)90430-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197608192950804"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.05.052"},{"issue":"4","key":"e_1_2_8_20_1","first-page":"381","article-title":"Decreased fluidity of isolated erythrocyte membranes in type 1 and type 2 diabetes. 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