{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:10:57Z","timestamp":1772766657770,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allogenic blood transfusions can lead to immunomodulation. Our purpose was to investigate whether perioperative transfusions were associated with postoperative infections and any other adverse events (AEs), after adjusting for potential confounding factors, following common elective lumbar spinal surgery procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design and methods<\/jats:title><jats:p>We performed a multivariate, propensity\u2010score matched, regression\u2010adjusted retrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program database between 2012 and 2016. All lumbar spinal surgery procedures were identified (<jats:italic>n<\/jats:italic>\u00a0=\u00a0174,891). A transfusion group (perioperative transfusion within 72\u2009h before, during, or after principal surgery; <jats:italic>n<\/jats:italic>\u00a0=\u00a01992) and a control group (no transfusion; <jats:italic>n<\/jats:italic>\u00a0=\u00a01992) were formed. Following adjustment for between\u2010group baseline features, adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) were calculated using a multivariate logistic regression model for any surgical site infection (SSI), superficial SSI, deep SSI, wound dehiscence, pneumonia, urinary tract infection, sepsis, any infection, mortality, and any AEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Transfusion was associated with an increased risk of each specific infection, mortality, and any AEs. Statistically significant between\u2010group differences were demonstrated with respect to any SSI (aOR: 1.48; 95% CI: 1.01\u20132.16), deep SSI (aOR: 1.66; 95% CI: 0.98\u20132.85), sepsis (aOR: 2.69; 95% CI: 1.43\u20135.03), wound dehiscence (aOR: 2.27; 95% CI: 0.86\u20136.01), any infection (aOR: 1.46; 95% CI: 1.13\u20131.88), any AEs (aOR: 1.80; 95% CI: 1.48\u20132.18), and mortality (aOR: 2.17; 95% CI: 0.77\u20136.36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We showed an association between transfusion and infection in lumbar spine surgery after adjustment for various applicable covariates. Sepsis had the highest association with transfusion. Our results reinforce a growing trend toward minimizing perioperative transfusions, which may lead to reduced infections following lumbar spine surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16864","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T14:05:12Z","timestamp":1648303512000},"page":"1027-1033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Allogeneic blood transfusions and infection risk in lumbar spine surgery: An American College of Surgeons National Surgery Quality Improvement Program Study"],"prefix":"10.1111","volume":"62","author":[{"given":"Amedeo","family":"Falsetto","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-3290","authenticated-orcid":false,"given":"Darren M.","family":"Roffey","sequence":"additional","affiliation":[{"name":"uOttawa Combined Adult Spinal Surgery Program, The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussam","family":"Jabri","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"uOttawa Combined Adult Spinal Surgery Program, The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Division of Neurosurgery The Ottawa Hospital  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen P.","family":"Kingwell","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"uOttawa Combined Adult Spinal Surgery Program, The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Division of Orthopaedic Surgery The Ottawa Hospital  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Stratton","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"uOttawa Combined Adult Spinal Surgery Program, The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Division of Orthopaedic Surgery The Ottawa Hospital  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"uOttawa Combined Adult Spinal Surgery Program, The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Division of Orthopaedic Surgery The Ottawa Hospital  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene K.","family":"Wai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"uOttawa Combined Adult Spinal Surgery Program, The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Division of Orthopaedic Surgery The Ottawa Hospital  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2012.01180.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.10.012"},{"key":"e_1_2_9_4_1","unstructured":"PfuntnerA WierLM StocksC.Most frequent procedures performed in U.S. hospitals 2011: statistical brief #165. 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