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The Brazilian program has 5 participating hemocenters. A Center for Transfusion Laboratory Studies (CTLS) and a Data Coordinating Center (DCC) support synergistic studies and activities over the 7\u2010year REDS\u2010IV\u2010P program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The US is building a centralized, vein\u2010to\u2010vein (V2V) database, linking information collected from blood donors, their donations, the resulting manufactured components, and data extracts from hospital electronic medical records of transfused and non\u2010transfused patients. Simultaneously, the Brazilian program is building a donor, donation, and component database. The databases will serve as the backbone for retrospective and prospective observational studies in transfusion epidemiology, transfusion recipient outcomes, blood component quality, and emerging blood safety issues. Special focus will be on preterm infants, patients with sickle cell disease, thalassemia or cancer, and the effect of donor biologic variability and component manufacturing on recipient outcomes. A rapid response capability to emerging safety threats has resulted in timely studies related to Severe Acute Respiratory Syndrome Corona Virus\u20102 (SARS\u2010CoV\u20102).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The REDS\u2010IV\u2010P program endeavors to improve donor\u2010recipient\u2010linked research with a focus on children and special populations while also maintaining the flexibility to address emerging blood safety issues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.16869","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T01:06:51Z","timestamp":1650416811000},"page":"982-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["The Recipient Epidemiology and Donor Evaluation\n                    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