{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:57:24Z","timestamp":1792799844243,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008935","name":"Center of Excellence in Regulatory Science and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008935","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blood transfusions are a vital component of modern healthcare, yet adverse reactions to blood product transfusions can cause morbidity, and rarely result in mortality. Therefore, accurate reporting of transfusion related adverse events (TRAEs) is paramount to improved transfusion practice. This study aims to investigate real\u2010world data (RWD) on TRAEs by evaluating differences between ICD 9\/10\u2010based electronic health records (EHR) and blood bank\u2010specific reporting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>TRAE data were retrospectively collected from a blood bank\u2010specific database between Jan 2015 and June 2019 as the reference data source and compared it to ICD 9\/10 diagnostic codes corresponding to various TRAEs. Seven reactions that have corresponding ICD 9\/10 diagnostic codes were evaluated: Transfusion related circulatory overload (TACO), transfusion related acute lung injury (TRALI), febrile non\u2010hemolytic reaction (FNHTR), transfusion\u2010related anaphylactic reaction (TRA), acute hemolytic transfusion reaction (AHTR), delayed hemolytic transfusion reaction (DHTR), and delayed serologic reaction (DSTR). These accounted for 33% of the TRAEs at an academic institution during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 18637 adult blood transfusion recipients, there were 229 unique patients with 263 TRAE related ICD codes in the EHR, while there were 191 unique patients with 287 TRAEs identified in the blood bank database. None of the categories of reaction we investigated had perfect alignment between ICD 9\/10 codes and blood bank specific diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Multiple systemic challenges were identified that hinder effective reporting of TRAEs. Identifying factors causing inconsistent reporting between blood banks and EHRs is paramount to developing effective workability between these electronic systems, as well as across clinical and laboratory teams.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16880","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T08:01:43Z","timestamp":1650355303000},"page":"1019-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Analyzing real world data of blood transfusion adverse events: Opportunities and challenges"],"prefix":"10.1111","volume":"62","author":[{"given":"Perrin","family":"Jhaveri","sequence":"first","affiliation":[{"name":"School of Medicine Stanford University  Stanford California USA"},{"name":"Stanford Blood Center  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selen","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Medicine (Biomedical Informatics) Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Moyal","sequence":"additional","affiliation":[{"name":"Department of Medicine (Biomedical Informatics) Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-1224","authenticated-orcid":false,"given":"Artur","family":"Belov","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology, US FDA  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Anderson","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology, US FDA  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Shan","sequence":"additional","affiliation":[{"name":"School of Medicine Stanford University  Stanford California USA"},{"name":"Stanford Blood Center  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6311-6268","authenticated-orcid":false,"given":"Barbee","family":"Whitaker","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology, US FDA  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-3455","authenticated-orcid":false,"given":"Tina","family":"Hernandez\u2010Boussard","sequence":"additional","affiliation":[{"name":"School of Medicine Stanford University  Stanford California USA"},{"name":"Department of Medicine (Biomedical Informatics) Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-017-0504-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2016.09.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00123.x"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"S1","article-title":"Slowing decline in blood collection and transfusion in the United States \u2010 2017","volume":"60","author":"Jones JM","year":"2020","journal-title":"Transfusion"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12215"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13676"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-599"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03535.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.186"},{"issue":"2","key":"e_1_2_7_11_1","first-page":"S10","article-title":"Transfusion\u2010associated adverse events and implementation of blood safety measures \u2010 findings from the 2017 National Blood Collection and utilization survey","volume":"60","author":"Savinkina AA","year":"2020","journal-title":"Transfusion"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14370"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2005.00444.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2325"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.3.660"},{"key":"e_1_2_7_16_1","unstructured":"U.S. Centers for Disease Control and Prevention.The National Healthcare Safety Network (NHSN) Manual: Biovigilance Component v2.6. Atlanta GA: Division of Healthcare Quality Promotion National Center for Emerging and Zoonotic Infectious Diseases 2021."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13730"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971201)80:11<2040::AID-CNCR2>3.0.CO;2-0"},{"key":"e_1_2_7_19_1","first-page":"479","article-title":"Interdisciplinary approach towards a systems medicine toolbox using the example of inflammatory diseases","volume":"18","author":"Bauer CR","year":"2017","journal-title":"Brief Bioinform"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12234"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12547"},{"key":"e_1_2_7_22_1","first-page":"1","article-title":"Medical chart validation of inpatient diagnosis codes for transfusion related acute lung injury 2013\u20102015","volume":"61","author":"Fuller Candace C","year":"2021","journal-title":"Transfusion"},{"key":"e_1_2_7_23_1","first-page":"1","article-title":"Transfusion\u2010related acute lung injury (TRALI) occurrence, risk factors, and outcome: a nested case\u2010control study","volume":"9","author":"Sridhar G","year":"2013","journal-title":"Int J Hematol"},{"key":"e_1_2_7_24_1","first-page":"23","article-title":"Validation of algorithms used to identify red blood cell transfusion related admissions in veteran patients with end stage renal disease","volume":"7","author":"Peters CB","year":"2019","journal-title":"EGEMS (Wash DC)"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCN.0b013e3181a91b58"},{"key":"e_1_2_7_26_1","unstructured":"CCBBA. (2021).ISBT 128 standard: product description code database (p. 13). ICCBBA."}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.16880","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.16880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T15:03:56Z","timestamp":1692975836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.16880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,19]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/trf.16880"],"URL":"https:\/\/doi.org\/10.1111\/trf.16880","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,19]]},"assertion":[{"value":"2021-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}