{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:58:31Z","timestamp":1792418311859,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001023","name":"Amon G. Carter Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transfusion carries a risk of transfusion reaction that is often underdiagnosed due to reliance on passive reporting. The study investigated the utility of digital methods to identify potential transfusion reactions, thus allowing real\u2010time intervention for affected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The hemovigilance unit monitored 3856 patients receiving 43,515 transfusions under the hemovigilance program. Retrospective comparison data included 298,498 transfusions. Transfusion medicine physicians designed and validated algorithms in the electronic health record that analyze discrete data, such as vital sign changes, to assign a risk score during each transfusion. Dedicated hemovigilance nurses remotely monitor all patients and perform real\u2010time chart reviews prioritized by risk score. When a reaction is suspected, a hemovigilance trained licensed clinician responds to manage the patient and ensure data collection. Board\u2010certified transfusion medicine physicians reviewed data and classified transfusion reactions under various categories according to the Centers for Disease Control hemovigilance definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Transfusion medicine physicians diagnosed 564 transfusion reactions (1.3% of transfusions)\u2014a 524% increase compared to the previous passive reporting. The rapid response provider reached the bedside on average at 12.4\u2009min demonstrating logistic feasibility. While febrile reactions were most diagnosed, recognition of transfusion\u2010associated circulatory overload demonstrated the greatest relative increase. Auditing and education programs further enhanced transfusion reaction awareness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The model of digitally\u2010enabled expert real\u2010time review of clinical data that prompts rapid response improved recognition of transfusion reactions. This approach could be applied to other patient deterioration events such as early identification of sepsis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.16882","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T13:09:51Z","timestamp":1650460191000},"page":"1010-1018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Digitally enabled hemovigilance allows real time response to transfusion reactions"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0400-5138","authenticated-orcid":false,"given":"Colleen","family":"Villamin","sequence":"first","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Division of Nursing The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonita","family":"Bates","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Division of Nursing The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Mescher","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Benitez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Martinez","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Knopfelmacher","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayrin","family":"Correa Medina","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitava","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Jaffray","sequence":"additional","affiliation":[{"name":"Division of Information Services The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Division of Diagnostic Imaging The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Division of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Porter","sequence":"additional","affiliation":[{"name":"Division of Nursing The University of Texas MD Anderson Cancer Center  Houston Texas 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