{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:19:53Z","timestamp":1788347993655,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018905","name":"Brockman Foundation","doi-asserted-by":"publisher","award":["Pro00078573"],"award-info":[{"award-number":["Pro00078573"]}],"id":[{"id":"10.13039\/501100018905","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chagas disease is a parasitic infection that can insidiously cause non\u2010ischemic cardiomyopathy. Given the largely silent nature of this progressive disease, asymptomatic blood donors pose potential blood transfusion risk. Blood donation screening has become an unintentional form of Chagas disease surveillance, with thousands of new cases identified since national surveillance was initiated in 2007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We recruited <jats:italic>T. cruzi<\/jats:italic>\u2010positive blood donors identified from California and Arizona blood centers for confirmatory blood screening and assessment of lifetime infection risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among eight suspected cases, we identified four confirmed US autochthonous infections. The current manuscript details the transmission sources, healthcare\u2010seeking behaviors post\u2010blood donation resulting, and clinical course of disease among persons without any history of travel to endemic Latin American countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This manuscript presents four additional US\u2010acquired Chagas disease cases and identifies an opportunity for blood centers to assist in confronting barriers surrounding Chagas disease in the US.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17026","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T16:34:05Z","timestamp":1658939645000},"page":"1808-1817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Evidence of likely autochthonous Chagas disease in the southwestern United States: A case series of <i>Trypanosoma cruzi<\/i> seropositive blood donors"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-3947","authenticated-orcid":false,"given":"Mary K.","family":"Lynn","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics Arnold School of Public Health University of South Carolina  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyndall C.","family":"Dye\u2010Braumuller","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Arnold School of Public Health University of South Carolina  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3032-5741","authenticated-orcid":false,"given":"Norman L.","family":"Beatty","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases &amp; 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