{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:44:32Z","timestamp":1790635472538,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR002535"],"award-info":[{"award-number":["UL1 TR002535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017570","name":"Tokyo Shinagawa Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thalassemia is a common genetic disease in Southeast Asia. Red blood cell (RBC) transfusion is an essential treatment for severe forms of thalassemia. We performed a study to demonstrate RBC alloimmunization and other transfusion\u2010related complications in patients with transfusion\u2010dependent thalassemia (TDT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>A multi\u2010center web\u2010based registry of TDT was conducted in eight medical centers across Thailand. Thalassemia information, transfusion therapy, and transfusion\u2010related complications were collected. Factors associated with each complication were demonstrated using the logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1000 patients recruited for the study, 449 were males (44.9%). The mean age was 23.9\u2009\u00b1\u200915.4\u2009years. The majority of patients, 738 (73.8%) had hemoglobin E\/beta\u2010thalassemia. In the study, 421 transfusion\u2010related complications were reported from 357 patients (35.7%). Alloimmunization was the most common complication which was found in 156 patients (15.6%) with 284 positive antibody tests. The most frequent antibodies against RBC were anti\u2010E (80\/284, 28.2%) followed by anti\u2010Mi<jats:sup>a<\/jats:sup> (45\/284, 15.8%) and anti\u2010c (32\/284, 11.3%). Age \u22653\u2009years at initial blood transfusion, splenomegaly, higher frequencies, and volumes of transfusion were significant factors associated with alloimmunization. None of the patients had to terminate blood transfusion due to multiple alloantibodies. Other commonly seen complications were allergic reactions (130, 13.0%), autoimmune hemolytic anemia (70, 7.0%) and febrile non\u2010hemolytic transfusion reaction (54, 5.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transfusion\u2010related complications, especially alloimmunization, were common among Thai patients with TDT. Extended RBC antigen\u2010matching for the Rh system and Mi<jats:sup>a<\/jats:sup> should be implemented to prevent the development of alloantibodies in multi\u2010transfused patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17068","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T10:49:39Z","timestamp":1660992579000},"page":"2039-2047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Red blood cell alloimmunization and other transfusion\u2010related complications in patients with transfusion\u2010dependent thalassemia: A multi\u2010center study in Thailand"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2364-1498","authenticated-orcid":false,"given":"Nattiya","family":"Teawtrakul","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Srinagarind Hospital, Faculty of Medicine Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-0248","authenticated-orcid":false,"given":"Duantida","family":"Songdej","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-3789","authenticated-orcid":false,"given":"Chattree","family":"Hantaweepant","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2381-9292","authenticated-orcid":false,"given":"Adisak","family":"Tantiworawit","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Thalassemia and Hematology Center, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-8022","authenticated-orcid":false,"given":"Supanun","family":"Lauhasurayotin","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitti","family":"Torcharus","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Department of Pediatrics Phramongkutklao College of Medicine  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-0714","authenticated-orcid":false,"given":"Pornpun","family":"Sripornsawan","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Prince of Songkla University  Songkla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranee","family":"Sutcharitchan","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4180-8041","authenticated-orcid":false,"given":"Pacharapan","family":"Surapolchai","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Thammasat University  Pathumthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6804-9121","authenticated-orcid":false,"given":"Patcharee","family":"Komvilaisak","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4473-9216","authenticated-orcid":false,"given":"Supawee","family":"Saengboon","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine Thammasat University  Pathumthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4204-0118","authenticated-orcid":false,"given":"Bunchoo","family":"Pongtanakul","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-9177","authenticated-orcid":false,"given":"Pimlak","family":"Charoenkwan","sequence":"additional","affiliation":[{"name":"Thalassemia and Hematology Center, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Division of Hematology and Oncology, Department of Pediatrics Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Red Blood Cell Disorders Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.036673"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2017.11.008"},{"key":"e_1_2_7_4_1","first-page":"498","article-title":"Haemoglobinopathies in southeast Asia","volume":"134","author":"Fucharoen S","year":"2011","journal-title":"Indian J Med Res"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011734"},{"issue":"5","key":"e_1_2_7_6_1","first-page":"649","article-title":"Genetic modifiers of beta\u2010thalassemia","volume":"90","author":"Thein SL","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07650.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(12)70011-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.278"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26316"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.10.3369"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14875"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04104-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2019.102678"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78333-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16590"},{"issue":"1","key":"e_1_2_7_18_1","first-page":"4","article-title":"Red blood cell alloimmunisation in transfusion\u2010dependent thalassaemia: a systematic review","volume":"17","author":"Franchini M","year":"2019","journal-title":"Blood Transfus Trasfus Sangue"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1990.tb02055.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2018.11.006"},{"key":"e_1_2_7_21_1","unstructured":"CappelliniMD CohenA PorterJ TaherA ViprakasitV.Guidelines for the management of transfusion dependent Thalassaemia (TDT).Thalassaemia International Federation;2014Available from:https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK269382\/"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03570.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12420"},{"key":"e_1_2_7_25_1","first-page":"216","volume-title":"Guidelines for the management of anemia and thalassemia","author":"Red Cell Disorders Subcommittee Thai Society of Hematology","year":"2020"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1987.tb02999.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03234.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006073222301"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.7.1431.1431"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0016-OA"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14508"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2019.102342"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0041-1132.2003.00589.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12827"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14359"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16855"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17068","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.17068","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T23:14:18Z","timestamp":1692659658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,20]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/trf.17068"],"URL":"https:\/\/doi.org\/10.1111\/trf.17068","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,20]]},"assertion":[{"value":"2022-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}