{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:11:42Z","timestamp":1782159102067,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR 301852"],"award-info":[{"award-number":["CIHR 301852"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP ID 1085942"],"award-info":[{"award-number":["APP ID 1085942"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transfusion Requirements in Cardiac Surgery III (TRICS III), a multi\u2010center randomized controlled trial, demonstrated clinical non\u2010inferiority for restrictive versus liberal RBC transfusion for patients undergoing cardiac surgery. However, it is uncertain if transfusion strategy affects long\u2010term health\u2010related quality of life (HRQOL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>In this planned sub\u2010study of Australian patients in TRICS III, we sought to determine the non\u2010inferiority of restrictive versus liberal transfusion strategy on long\u2010term HRQOL and to describe clinical outcomes 24\u2009months postoperatively. The restrictive strategy involved transfusing RBCs when hemoglobin was &lt;7.5\u00a0g\/dl; the transfusion triggers in the liberal group were:\u2009&lt;9.5\u00a0g\/L intraoperatively, &lt;9.5\u00a0g\/L in intensive care, or &lt;8.5\u00a0g\/dl on the ward. HRQOL assessments were performed using the 36\u2010item short form survey version 2 (SF\u201036v2). Primary outcome was non\u2010inferiority of summary measures of SF\u201036v2 at 12\u2009months, (non\u2010inferiority margin: \u22120.25 effect size; restrictive minus liberal scores). Secondary outcomes included non\u2010inferiority of HRQOL at 18 and 24\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six hundred seventeen Australian patients received allocated randomization; HRQOL data were available for 208\/311 in restrictive and 217\/306 in liberal group. After multiple imputation, non\u2010inferiority of restrictive transfusion at 12\u2009months was not demonstrated for HRQOL, and the estimates were directionally in favor of liberal transfusion. Non\u2010inferiority also could not be concluded at 18 and 24\u2009months. Sensitivity analyses supported these results. There were no differences in quality\u2010adjusted life years or composite clinical outcomes up to 24\u2009months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The non\u2010inferiority of a restrictive compared to a liberal transfusion strategy was not established for long\u2010term HRQOL in this dataset.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17084","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T13:24:45Z","timestamp":1662470685000},"page":"1973-1983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Health\u2010related quality of life after restrictive versus liberal RBC transfusion for cardiac surgery: Sub\u2010study from a randomized clinical trial"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-0600","authenticated-orcid":false,"given":"Raymond 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