{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:17:26Z","timestamp":1775042246742,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6\u20102018\u20100033"],"award-info":[{"award-number":["6\u20102018\u20100033"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypotensive transfusion reaction (HyTR) is rare. It is characterized by a rapid onset of hypotension during transfusion, which usually resolves quickly upon cessation of transfusion. Information on the incidence and clinical characteristics of HyTR has been reported in only a few studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We retrospectively reviewed HyTR cases from 10\u2010year hemovigilance data in a tertiary care hospital in Seoul, Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 37 HyTRs in 35 patients, and the overall incidence of HyTR was 0.50 per 10,000 transfused units. Among the blood components, the incidence of HyTR was highest in filtered random donor platelets (0.75 per 10,000\u2009units). About half of the HyTRs occurred within 15\u2009min after the start of transfusion (19\/37). Blood pressure returned to the normal range within an hour in 73.0% of the cases (27\/37). All HyTR cases recovered without severe complications. Known risk factors for HyTR were not prominent in our cohort of patients, with no patients taking angiotensin\u2010converting enzyme inhibitors and only five patients transfused with bedside filtered platelets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>HyTR can occur in patients with various conditions and types of blood components. Understanding the clinical characteristics of HyTR facilitates proper management, leading to improved transfusion safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17099","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T07:19:40Z","timestamp":1662967180000},"page":"2245-2253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Incidence and characteristics of hypotensive transfusion reaction: 10\u2010year experience in a single center"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-9284","authenticated-orcid":false,"given":"Soon Sung","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2609-8945","authenticated-orcid":false,"given":"Sinyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Ok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-833988"},{"key":"e_1_2_8_3_1","volume-title":"Transfusion reactions","author":"Robitaille N","year":"2021"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1995.351196110903.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38498257382.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011093431918"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41010136.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38498257383.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1998.7510018.x"},{"key":"e_1_2_8_10_1","unstructured":"Centers for Disease Control and Prevention.National healthcare safety network biovigilance component hemovigilance module surveillance protocol. Protocol v2.6. Available from:https:\/\/www.cdc.gov\/nhsn\/pdfs\/biovigilance\/bv\u2010hv\u2010protocol\u2010current.pdf."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.04057.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13047"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01313-6"},{"key":"e_1_2_8_14_1","unstructured":"Direction des risques biologiques et de la sant\u00e9 au travail.Les incidents et accidents transfusionnels signal\u00e9s au syst\u00e8me d'h\u00e9movigilance du Qu\u00e9bec en. Available from:https:\/\/www.inspq.qc.ca\/sites\/default\/files\/publications\/2586_incidents_accidents_tranfusionnels_2017.pdf(2017)."},{"key":"e_1_2_8_15_1","unstructured":"Public Health Agency of Canada.Transfusion transmitted injuries surveillance system (TTISS): 2011\u20102015 summary results. 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