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We collected biological and behavioral data from urban gay, bisexual, and other men who have sex with men (GBM) to inform the use of this approach in Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design and methods<\/jats:title>\n                    <jats:p>Engage is a closed prospective cohort of sexually active GBM, aged 16+ years, recruited via respondent\u2010driven\u2010sampling (RDS) in Montreal, Toronto, and Vancouver, Canada. Participants completed a questionnaire on behaviors (past 6\u00a0months) and tested for HIV and sexually transmitted and blood\u2010borne infections at each visit. Rate ratios for HIV infection and predictive values for blood donation eligibility criteria were estimated by RDS\u2010adjusted Poisson regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data on 2008 (study visits 2017\u201002 to 2021\u201008) HIV\u2010negative participants were used. The HIV incidence rate for the three cities was 0.4|100 person\u2010years [95%CI:0.3, 0.6]. HIV seroconversion was associated with age\u2009&lt;30\u2009years: adjusted rate ratio (aRR) 9.1 [95%CI:3.2, 26.2], 6\u201310 and\u2009&gt;10 anal sex partners versus 1\u20136 aRR: 5.3 [2.1,13.5] and 8.4 [3.4, 20.9], and use of crystal methamphetamine during sex: 4.2 [1.5, 11.6]. Applying the combined selection criteria: drug injection, \u22652 anal sex partners, and a new anal sex partner, detected all participants who seroconverted (100% sensitivity, 100% negative predictive value), and would defer 63% of study participants from donating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Using three screening questions regarding drug injection and sexual behaviors in the past 6 months would correctly identify potential GBM donors at high risk of having recently contracted HIV. Doing so would reduce the proportion of deferred sexually active GBM by one\u2010third.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.17127","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T08:29:39Z","timestamp":1664958579000},"page":"2555-2567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>HIV<\/scp>\n                    incidence and related risks among gay, bisexual, and other men who have sex with men in Montreal, Toronto, and Vancouver: Informing blood donor selection criteria in Canada"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0083-9722","authenticated-orcid":false,"given":"Gilles","family":"Lambert","sequence":"first","affiliation":[{"name":"Direction R\u00e9gionale de Sant\u00e9 Publique de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Institut National de Sant\u00e9 Publique du Qu\u00e9bec  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Cox","sequence":"additional","affiliation":[{"name":"Direction R\u00e9gionale de Sant\u00e9 Publique de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Epidemiology Biostatistics and Occupational Health, McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Fourmigue","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milada","family":"Dvorakova","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herak","family":"Apelian","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica E. M.","family":"Moodie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Biostatistics and Occupational Health, McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Grace","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayna","family":"Skakoon\u2010Sparling","sequence":"additional","affiliation":[{"name":"Department of Psychology Toronto Metropolitan University  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Moore","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS  Vancouver British Columbia Canada"},{"name":"Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Lachowsky","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS  Vancouver British Columbia Canada"},{"name":"School of Public Health and Social Policy University of Victoria  Victoria British Columbia Canada"},{"name":"Community\u2010Based Research Centre  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jody","family":"Jollimore","sequence":"additional","affiliation":[{"name":"Community\u2010Based Research Centre  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Lal","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbie","family":"Parlette","sequence":"additional","affiliation":[{"name":"Department of Psychology Toronto Metropolitan University  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor A.","family":"Hart","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Department of Psychology Toronto Metropolitan University  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Engage Study Team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.WHO Expert Committee on Biological Standardization sixty\u2010seventh report. 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