{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:34:50Z","timestamp":1756895690426,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A paucity of data exists about the current practice of fetal red blood cell (RBC) transfusion in the United States (US). This investigation describes intrauterine transfusion (IUT) RBC product selection and processing practices at different US institutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A transfusion medicine and maternal\u2010fetal medicine (MFM) team designed a survey to interrogate and characterize RBCs utilized for IUT. This survey was distributed to seventy US institutions with fetal treatment centers (October 2020\u2013April 2021) identified through the NAFTNet (North American Fetal Therapy Network).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven institutions responded (response rate 53%, 37\/70), but five were excluded for not performing IUTs. Most (84%; 27\/32) performed 1\u201324 IUTs annually; two performed &gt;50 IUTs\/year. Group O, Rh(D) negative RBC units were always used by 66% (21\/32), and 75% (24\/32) provided hemoconcentrated RBCs by washing (17\/24) or dry packing (6\/24). Overall, 66% (21\/32) targeted a hematocrit \u226575%. Fifty percent provided both leukocyte\u2010reduced and CMV\u2010negative RBC units. Irradiation of RBC units was performed within 6\u2009h of issue at 63% (20\/32) of sites. Most (81%, 26\/32) used RBC units at &lt;7\u2009days of age after collection, 56% (18\/32) always provided washed RBC units, while 19% (6\/32) issued washed RBC only if fresh units are unavailable. Implicated maternal RBC alloantibodies were matched for 78% (25\/32) of the time. The transfused volume was universally determined by the MFMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Heterogeneity and lack of standardization exist in RBC product selection and special processing steps for IUTs in the US. Hence, the establishment of a consensus to standardize IUT protocols is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17134","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T10:55:23Z","timestamp":1664880923000},"page":"2449-2453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Survey of intrauterine red blood cell (<scp>RBC<\/scp>) transfusion practices in the United States"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7896-2459","authenticated-orcid":false,"given":"Sara","family":"Bakhtary","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine UCSF  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tachjaree","family":"Panchalee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology UCSF  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-2800","authenticated-orcid":false,"given":"Elizabeth P.","family":"Crowe","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine and Pediatric Hematology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa E.","family":"Schwab","sequence":"additional","affiliation":[{"name":"Department of Surgery UCSF  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulhafiz","family":"Zakieh","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine and Pediatric Hematology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-991X","authenticated-orcid":false,"given":"Cassandra D.","family":"Josephson","sequence":"additional","affiliation":[{"name":"Department of Oncology and Cancer and Blood Disorders Institute Johns Hopkins Univ SOM, Baltimore MD and Johns Hopkins All Children\u2019s Hospital  St. Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasim C.","family":"Sobhani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences UCSF  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan M.","family":"Gonzalez\u2010Velez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences UCSF  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-9905","authenticated-orcid":false,"given":"Ruchika","family":"Goel","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine and Pediatric Hematology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.09.024"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2019.1647521"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.01.059"},{"volume-title":"Transfusion therapy: clinical principles and practice","year":"2019","author":"Marques M","key":"e_1_2_7_5_1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362812"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4966"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-697110"},{"volume-title":"Perinatal issues in transfusion practice","year":"2020","author":"CS C","key":"e_1_2_7_11_1"},{"issue":"4","key":"e_1_2_7_12_1","first-page":"271","article-title":"Determining the volume of blood required for the correction of foetal anaemia by intrauterine transfusion during pregnancies of Rh isoimmunised women","volume":"8","author":"Santiago MD","year":"2010","journal-title":"Blood Transfus"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12338"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12192"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1993.33793325059.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13478"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31826d7dc1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2018.02.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12902"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17319"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13231"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.17134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T15:23:44Z","timestamp":1692545024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,4]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/trf.17134"],"URL":"https:\/\/doi.org\/10.1111\/trf.17134","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2022,10,4]]},"assertion":[{"value":"2022-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}