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Strategies to improve resource allocation in this setting are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed a custom\u2010made, computerized system to manage the inventory and allocation of COVID\u201019 convalescent plasma (CCP) in a multi\u2010site RCT, CONCOR\u20101. A hub\u2010and\u2010spoke distribution model enabled real\u2010time inventory monitoring and assignment for randomization. A live CCP inventory system using REDCap was programmed for spoke sites to reserve, assign, and order CCP from hospital hubs. A data\u2010driven mixed\u2010integer programming model with supply and demand forecasting was developed to guide the equitable allocation of CCP at hubs across Canada (excluding Qu\u00e9bec).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>18\/38 hospital study sites were hubs with a median of 2 spoke sites per hub. A total of 394.5 500\u2010ml doses of CCP were distributed; 349.5 (88.6%) doses were transfused; 9.5 (2.4%) were wasted due to mechanical damage sustained to the blood bags; 35.5 (9.0%) were unused at the end of the trial. Due to supply shortages, 53\/394.5 (13.4%) doses were imported from H\u00e9ma\u2010Qu\u00e9bec to Canadian Blood Services (CBS), and 125 (31.7%) were transferred between CBS regional distribution centers to meet demand. 137\/349.5 (39.2%) and 212.5 (60.8%) doses were transfused at hubs and spoke sites, respectively. The mean percentages of total unmet demand were similar across the hubs, indicating equitable allocation, using our model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Computerized tools can provide efficient and immediate solutions for equitable allocation decisions of scarce blood products in RCTs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17151","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T10:46:31Z","timestamp":1666781191000},"page":"2525-2538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A <scp>data\u2010informed<\/scp> system to manage scarce blood product allocation in a randomized controlled trial of convalescent plasma"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4803-0984","authenticated-orcid":false,"given":"Na","family":"Li","sequence":"first","affiliation":[{"name":"Department of Community Health Sciences University of Calgary  Calgary Alberta Canada"},{"name":"McMaster Centre for Transfusion Research, Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Department of Computing and Software McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle P.","family":"Zeller","sequence":"additional","affiliation":[{"name":"McMaster Centre for Transfusion Research, Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine, Michael G. 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