{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T05:29:13Z","timestamp":1774243753937,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemolytic disease of the fetus and newborn (HDFN) is a challenging condition that may necessitate the need for intrauterine or neonatal transfusion. The ability to provide compatible blood depends on antibody identification and antigen prevalence. We describe the case of a newborn that was affected by HDFN secondary to a high\u2010prevalence antigen of unknown specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>A 29\u2010year\u2010old mother underwent emergency cesarean section for fetal distress. The newborn had severe anemia and hyperbilirubinemia. Antibody screening and identification on maternal plasma revealed pan reactivity with negative autocontrol. The cord sample had the same pattern with positive Direct Antiglobulin Test. Incompatible group O red blood cells were transfused to the newborn with no complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Testing the maternal sample at a reference laboratory revealed the presence of anti\u2010U at a high titer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In life\u2010threatening conditions, it may be necessary to transfuse incompatible units. In patients who require transfusion in the presence of an identified antibody against a high\u2010prevalence antigen, sources for rare blood should be explored. These include autologous donations for adults, collecting blood from relatives (including mothers), and fresh or frozen units from rare donors through rare donor registries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17204","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T10:38:16Z","timestamp":1675766296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Incompatible red blood cell transfusion for hemolytic disease of the fetus and newborn secondary to <scp>anti\u2010U<\/scp>: A case report"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3272-2393","authenticated-orcid":false,"given":"Maha A.","family":"Badawi","sequence":"first","affiliation":[{"name":"Department of Hematology, Faculty of Medicine King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"Blood Transfusion Services Unit King Abdulaziz University Hospital  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Al\u2010Wassia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-240"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0041-87812003000600006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.15372995.1976.16476247058.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13806"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/pm-21-72"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmab099"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.17352\/2455-5282.000080"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2021-001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2013.10.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2007.00799.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12221"},{"key":"e_1_2_8_14_1","unstructured":"Rare Donors Resources.Isbtweb.org.https:\/\/www.isbtweb.org\/isbt-working-parties\/rare-donors\/resources.html. 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